Biomaterial Database

Cyproheptadine inhibits the corticotropin releasing hormone (CRH)--induced hormone release in normal subjects. 1987

B Allolio, and H M Schulte, and U Deuss, and W Winkelmann

Medizinische Universitätsklinik II, Köln, Germany.

To further elucidate the inhibitory action of cyproheptadine on ACTH release, we studied the influence of cyproheptadine (0.1 mg/kg body weight) on the corticotropin releasing hormone (CRH)--induced hormone release in normal subjects. On two occasions six healthy volunteers underwent a CRH-test (0.1 mg hCRH as bolus i.v.) combined with an infusion of either cyproheptadine or saline starting 30 min prior to the CRH injection. Cyproheptadine led to a significant suppression of the plasma ACTH (p less than 0.05) and serum cortisol (p less than 0.005) response to CRH compared to placebo suggesting a direct inhibitory action of cyproheptadine at the pituitary level.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D010902	Pituitary Gland	A small, unpaired gland situated in the SELLA TURCICA. It is connected to the HYPOTHALAMUS by a short stalk which is called the INFUNDIBULUM.	Hypophysis,Hypothalamus, Infundibular,Infundibular Stalk,Infundibular Stem,Infundibulum (Hypophysis),Infundibulum, Hypophyseal,Pituitary Stalk,Hypophyseal Infundibulum,Hypophyseal Stalk,Hypophysis Cerebri,Infundibulum,Cerebri, Hypophysis,Cerebrus, Hypophysis,Gland, Pituitary,Glands, Pituitary,Hypophyseal Stalks,Hypophyses,Hypophysis Cerebrus,Infundibular Hypothalamus,Infundibular Stalks,Infundibulums,Pituitary Glands,Pituitary Stalks,Stalk, Hypophyseal,Stalk, Infundibular,Stalks, Hypophyseal,Stalks, Infundibular
D003346	Corticotropin-Releasing Hormone	A peptide of about 41 amino acids that stimulates the release of ADRENOCORTICOTROPIC HORMONE. CRH is synthesized by neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, CRH stimulates the release of ACTH from the PITUITARY GLAND. CRH can also be synthesized in other tissues, such as PLACENTA; ADRENAL MEDULLA; and TESTIS.	ACTH-Releasing Hormone,CRF-41,Corticotropin-Releasing Factor,Corticotropin-Releasing Hormone-41,ACTH-Releasing Factor,CRF (ACTH),Corticoliberin,Corticotropin-Releasing Factor-41,ACTH Releasing Factor,ACTH Releasing Hormone,Corticotropin Releasing Factor,Corticotropin Releasing Factor 41,Corticotropin Releasing Hormone,Corticotropin Releasing Hormone 41
D003533	Cyproheptadine	A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.	Antergan,Dihexazin,Periactin,Peritol,Viternum
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006854	Hydrocortisone	The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.	Cortef,Cortisol,Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-,11-Epicortisol,Cortifair,Cortril,Epicortisol,Hydrocortisone, (11 alpha)-Isomer,Hydrocortisone, (9 beta,10 alpha,11 alpha)-Isomer,11 Epicortisol
D000324	Adrenocorticotropic Hormone	An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).	ACTH,Adrenocorticotropin,Corticotropin,1-39 ACTH,ACTH (1-39),Adrenocorticotrophic Hormone,Corticotrophin,Corticotrophin (1-39),Corticotropin (1-39),Hormone, Adrenocorticotrophic,Hormone, Adrenocorticotropic
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults

Related Publications

B Allolio, and H M Schulte, and U Deuss, and W Winkelmann

[Corticotropin-releasing hormone (CRH)].

March 1995, Nihon rinsho. Japanese journal of clinical medicine,

B Allolio, and H M Schulte, and U Deuss, and W Winkelmann

[Corticotropin-releasing hormone (CRH)].

December 1999, Nihon rinsho. Japanese journal of clinical medicine,

B Allolio, and H M Schulte, and U Deuss, and W Winkelmann

[Corticotropin-releasing hormone (CRH)].

July 2010, Nihon rinsho. Japanese journal of clinical medicine,

B Allolio, and H M Schulte, and U Deuss, and W Winkelmann

[Corticotropin-releasing hormone (CRH)].

August 2005, Nihon rinsho. Japanese journal of clinical medicine,

B Allolio, and H M Schulte, and U Deuss, and W Winkelmann

Androgen inhibits the increases in hypothalamic corticotropin-releasing hormone (CRH) and CRH-immunoreactivity following gonadectomy.

March 1994, Neuroendocrinology,

B Allolio, and H M Schulte, and U Deuss, and W Winkelmann

Terbutaline inhibits corticotropin-releasing hormone (CRH) expression in human trophoblast cells.

November 2006, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians,

B Allolio, and H M Schulte, and U Deuss, and W Winkelmann

Atrial natriuretic hormone inhibits corticotropin-releasing hormone-induced prolactin release in man.

January 1995, Journal of psychiatric research,

B Allolio, and H M Schulte, and U Deuss, and W Winkelmann

Stress-induced behaviors require the corticotropin-releasing hormone (CRH) receptor, but not CRH.

July 1999, Proceedings of the National Academy of Sciences of the United States of America,

B Allolio, and H M Schulte, and U Deuss, and W Winkelmann

Corticotropin-releasing hormone (CRH)-induced thyrotropin release is directly mediated through CRH receptor type 2 on thyrotropes.

December 2003, Endocrinology,

B Allolio, and H M Schulte, and U Deuss, and W Winkelmann

Corticotropin releasing hormone (CRH) in normal and pregnant uterus: physiological implications.

January 1996, Frontiers in bioscience : a journal and virtual library,