Biomaterial Database

Possible carcinogenic properties of a new chromogen, dicarboxydine (gamma,gamma'-3,3'-benzidine dioxydibutyric acid), tested in rats and mice. 1979

G B Pliss, and N I Volfson

The carcinogenic properties of gamma,gamma'-3,3'-benzidine dioxydibutyric acid [dicarboxydine (DCD)] were studied in 208 rats and 127 mice by either sc administration or by feeding of the compound for 24 months. Tumors developed in 21 of the 99 DCD-treated rats that survived to the time of the first tumor appearance. In DCD-treated rats, tumors different from those in the controls were noted in the bladder, prostate gland, uterine body, and other organs, but in single cases only. Four rats had sarcomas at the site of DCD injection. DCD had no carcinogenic effect in mice. In view of the longer times of tumor induction and multiple tumor development only in rats given sc injections of DCD, the conclusion was reached that DCD is of dubious or negative carcinogenicity.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009374	Neoplasms, Experimental	Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.	Experimental Neoplasms,Experimental Neoplasm,Neoplasm, Experimental
D002087	Butyrates	Derivatives of BUTYRIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxypropane structure.	Butyrate,n-Butyrate,Butanoic Acids,Butyric Acids,Acids, Butanoic,Acids, Butyric,n Butyrate
D002273	Carcinogens	Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.	Carcinogen,Oncogen,Oncogens,Tumor Initiator,Tumor Initiators,Tumor Promoter,Tumor Promoters,Initiator, Tumor,Initiators, Tumor,Promoter, Tumor,Promoters, Tumor
D004353	Drug Evaluation, Preclinical	Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.	Drug Screening,Evaluation Studies, Drug, Pre-Clinical,Drug Evaluation Studies, Preclinical,Drug Evaluations, Preclinical,Evaluation Studies, Drug, Preclinical,Evaluation, Preclinical Drug,Evaluations, Preclinical Drug,Medicinal Plants Testing, Preclinical,Preclinical Drug Evaluation,Preclinical Drug Evaluations,Drug Screenings,Screening, Drug,Screenings, Drug
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001560	Benzidines	Very toxic industrial chemicals. They are absorbed through the skin, causing lethal blood, bladder, liver, and kidney damage and are potent, broad-spectrum carcinogens in most species.	Bianilines,Biphenyldiamines
D015100	3,3'-Diaminobenzidine	A chemically and thermodynamically stable derivative of BENZIDINE.	3,3 Diaminobenzidine,3,3' Diaminobenzidine,3,3-Diaminobenzidine,Diaminobenzidine, 3,3,Diaminobenzidine, 3,3'
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus