BIOMAT Database Logo BIOMAT Database Logo

PPARβ/δ, a Novel Regulator for Vascular Smooth Muscle Cells Phenotypic Modulation and Vascular Remodeling after Subarachnoid Hemorrhage in Rats. 2017

Hongrong Zhang, and Li Jiang, and Zongduo Guo, and Jianjun Zhong, and Jingchuan Wu, and Junchi He, and Han Liu, and Zhaohui He, and Haitao Wu, and Chongjie Cheng, and Xiaochuan Sun
Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University, NO. 1 of Youyi Rd, Yuzhong District, Chongqing, China.

Cerebral vascular smooth muscle cell (VSMC) phenotypic switch is involved in the pathophysiology of vascular injury after aneurysmal subarachnoid hemorrhage (aSAH), whereas the molecular mechanism underlying it remains largely speculative. Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) has been implicated to modulate the vascular cells proliferation and vascular homeostasis. In the present study, we investigated the potential role of PPARβ/δ in VSMC phenotypic switch following SAH. Activation of PPARβ/δ by GW0742 and adenoviruses PPARβ/δ (Ad-PPARβ/δ) significantly inhibited hemoglobin-induced VSMC phenotypic switch. However, the effects of PPARβ/δ on VSMC phenotypic switch were partly obstacled in the presence of LY294002, a potent inhibitor of Phosphatidyl-Inositol-3 Kinase-AKT (PI3K/AKT). Furthermore, following study demonstrated that PPARβ/δ-induced PI3K/AKT activation can also contribute to Serum Response Factor (SRF) nucleus localization and Myocardin expression, which was highly associated with VSMC phenotypic switch. Finally, we found that Ad-PPARβ/δ positively modulated vascular remodeling in SAH rats, i.e. the diameter of basilar artery and the thickness of vessel wall. In addition, overexpression of PPARβ/δ by adenoviruses significantly improved neurological outcome. Taken together, this study identified PPARβ/δ as a useful regulator for VSMC phenotypic switch and vascular remodeling following SAH, providing novel insights into the therapeutic strategies of delayed cerebral ischemia.

UI MeSH Term Description Entries
D008297 Male Males
D009025 Morpholines Tetrahydro-1,4-Oxazines,Tetrahydro 1,4 Oxazines
D009131 Muscle, Smooth, Vascular The nonstriated involuntary muscle tissue of blood vessels. Vascular Smooth Muscle,Muscle, Vascular Smooth,Muscles, Vascular Smooth,Smooth Muscle, Vascular,Smooth Muscles, Vascular,Vascular Smooth Muscles
D010641 Phenotype The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment. Phenotypes
D002867 Chromones 1,4-Benzopyrones,Chromone,1,4 Benzopyrones
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013345 Subarachnoid Hemorrhage Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status. Hemorrhage, Subarachnoid,Perinatal Subarachnoid Hemorrhage,Subarachnoid Hemorrhage, Aneurysmal,Subarachnoid Hemorrhage, Spontaneous,SAH (Subarachnoid Hemorrhage),Subarachnoid Hemorrhage, Intracranial,Aneurysmal Subarachnoid Hemorrhage,Aneurysmal Subarachnoid Hemorrhages,Hemorrhage, Aneurysmal Subarachnoid,Hemorrhage, Intracranial Subarachnoid,Hemorrhage, Perinatal Subarachnoid,Hemorrhage, Spontaneous Subarachnoid,Hemorrhages, Aneurysmal Subarachnoid,Hemorrhages, Intracranial Subarachnoid,Hemorrhages, Perinatal Subarachnoid,Hemorrhages, Spontaneous Subarachnoid,Hemorrhages, Subarachnoid,Intracranial Subarachnoid Hemorrhage,Intracranial Subarachnoid Hemorrhages,Perinatal Subarachnoid Hemorrhages,SAHs (Subarachnoid Hemorrhage),Spontaneous Subarachnoid Hemorrhage,Spontaneous Subarachnoid Hemorrhages,Subarachnoid Hemorrhage, Perinatal,Subarachnoid Hemorrhages,Subarachnoid Hemorrhages, Aneurysmal,Subarachnoid Hemorrhages, Intracranial,Subarachnoid Hemorrhages, Perinatal,Subarachnoid Hemorrhages, Spontaneous
D017207 Rats, Sprague-Dawley A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company. Holtzman Rat,Rats, Holtzman,Sprague-Dawley Rat,Rats, Sprague Dawley,Holtzman Rats,Rat, Holtzman,Rat, Sprague-Dawley,Sprague Dawley Rat,Sprague Dawley Rats,Sprague-Dawley Rats
D047428 Protein Kinase Inhibitors Agents that inhibit PROTEIN KINASES. Protein Kinase Inhibitor,Inhibitor, Protein Kinase,Inhibitors, Protein Kinase,Kinase Inhibitor, Protein,Kinase Inhibitors, Protein
D047494 PPAR delta A nuclear transcription factor. It is activated by PROSTACYCLIN. PPARdelta,PPARD protein,Peroxisome Proliferator-Activated Receptor delta,Peroxisome Proliferator Activated Receptor delta

Related Publications

Hongrong Zhang, and Li Jiang, and Zongduo Guo, and Jianjun Zhong, and Jingchuan Wu, and Junchi He, and Han Liu, and Zhaohui He, and Haitao Wu, and Chongjie Cheng, and Xiaochuan Sun
Phenotypic modulation of smooth muscle cells and vascular remodeling in intraparenchymal small cerebral arteries after canine experimental subarachnoid hemorrhage.
July 2003, Neuroscience letters,
Hongrong Zhang, and Li Jiang, and Zongduo Guo, and Jianjun Zhong, and Jingchuan Wu, and Junchi He, and Han Liu, and Zhaohui He, and Haitao Wu, and Chongjie Cheng, and Xiaochuan Sun
Dedicator of cytokinesis 2, a novel regulator for smooth muscle phenotypic modulation and vascular remodeling.
May 2015, Circulation research,
Hongrong Zhang, and Li Jiang, and Zongduo Guo, and Jianjun Zhong, and Jingchuan Wu, and Junchi He, and Han Liu, and Zhaohui He, and Haitao Wu, and Chongjie Cheng, and Xiaochuan Sun
Surfactant Protein A, a Novel Regulator for Smooth Muscle Phenotypic Modulation and Vascular Remodeling-Brief Report.
February 2021, Arteriosclerosis, thrombosis, and vascular biology,
Hongrong Zhang, and Li Jiang, and Zongduo Guo, and Jianjun Zhong, and Jingchuan Wu, and Junchi He, and Han Liu, and Zhaohui He, and Haitao Wu, and Chongjie Cheng, and Xiaochuan Sun
Peroxisome proliferator‑activated receptor β/δ regulates cerebral vasospasm after subarachnoid hemorrhage via modulating vascular smooth muscle cells phenotypic conversion.
December 2021, Molecular medicine reports,
Hongrong Zhang, and Li Jiang, and Zongduo Guo, and Jianjun Zhong, and Jingchuan Wu, and Junchi He, and Han Liu, and Zhaohui He, and Haitao Wu, and Chongjie Cheng, and Xiaochuan Sun
Gax regulates human vascular smooth muscle cell phenotypic modulation and vascular remodeling.
January 2016, American journal of translational research,
Hongrong Zhang, and Li Jiang, and Zongduo Guo, and Jianjun Zhong, and Jingchuan Wu, and Junchi He, and Han Liu, and Zhaohui He, and Haitao Wu, and Chongjie Cheng, and Xiaochuan Sun
Investigating the Role of PPARβ/δ in Retinal Vascular Remodeling Using Pparβ/δ-Deficient Mice.
June 2020, International journal of molecular sciences,
Hongrong Zhang, and Li Jiang, and Zongduo Guo, and Jianjun Zhong, and Jingchuan Wu, and Junchi He, and Han Liu, and Zhaohui He, and Haitao Wu, and Chongjie Cheng, and Xiaochuan Sun
Janus Kinase 3, a Novel Regulator for Smooth Muscle Proliferation and Vascular Remodeling.
July 2017, Arteriosclerosis, thrombosis, and vascular biology,
Hongrong Zhang, and Li Jiang, and Zongduo Guo, and Jianjun Zhong, and Jingchuan Wu, and Junchi He, and Han Liu, and Zhaohui He, and Haitao Wu, and Chongjie Cheng, and Xiaochuan Sun
Phenotypic transformation of smooth muscle in vasospasm after aneurysmal subarachnoid hemorrhage.
June 2014, Translational stroke research,
Hongrong Zhang, and Li Jiang, and Zongduo Guo, and Jianjun Zhong, and Jingchuan Wu, and Junchi He, and Han Liu, and Zhaohui He, and Haitao Wu, and Chongjie Cheng, and Xiaochuan Sun
Rosuvastatin regulates vascular smooth muscle cell phenotypic modulation in vascular remodeling: role for the urokinase receptor.
December 2007, Atherosclerosis,
Hongrong Zhang, and Li Jiang, and Zongduo Guo, and Jianjun Zhong, and Jingchuan Wu, and Junchi He, and Han Liu, and Zhaohui He, and Haitao Wu, and Chongjie Cheng, and Xiaochuan Sun
Bexarotene Exerts Protective Effects Through Modulation of the Cerebral Vascular Smooth Muscle Cell Phenotypic Transformation by Regulating PPARγ/FLAP/LTB4 After Subarachnoid Hemorrhage in Rats.
January 2019, Cell transplantation,
Copied contents to your clipboard!