BIOMAT Database Logo BIOMAT Database Logo

Tritiated thymidine labeling index and response in human breast cancer. 1979

A Sulkes, and R B Livingston, and W K Murphy

Tumor cell uptake of tritiated thymidine, expressed as the labeling index (Ll), was determined prior to treatment of 25 patients with disseminated breast carcinoma. All patients subsequently received combination chemotherapy with adriamycin, cyclophosphamide, and an antimetabolite (usually 5-fluorouracil), with or without vincristine. The Ll was significantly higher in responders to chemotherapy than in nonresponders (mean, 15 vs. 7.1; P less than 0.01). Other pretreatment variables examined did not show a significant association with likelihood of response. Measurements of the tumor cell Ll in patients with accessible tumor may be of benefit in selection of treatment; 0 of 9 patients with an Ll less than 9 had a response in our series in contrast to 11 of 16 patients with an Ll greater than 9 who had a response (P = 0.001).

UI MeSH Term Description Entries
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011379 Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D012075 Remission, Spontaneous A spontaneous diminution or abatement of a disease over time, without formal treatment. Spontaneous Healing,Spontaneous Regression,Spontaneous Remission,Healing, Spontaneous,Regression, Spontaneous,Spontaneous Healings,Spontaneous Regressions
D001943 Breast Neoplasms Tumors or cancer of the human BREAST. Breast Cancer,Breast Tumors,Cancer of Breast,Breast Carcinoma,Cancer of the Breast,Human Mammary Carcinoma,Malignant Neoplasm of Breast,Malignant Tumor of Breast,Mammary Cancer,Mammary Carcinoma, Human,Mammary Neoplasm, Human,Mammary Neoplasms, Human,Neoplasms, Breast,Tumors, Breast,Breast Carcinomas,Breast Malignant Neoplasm,Breast Malignant Neoplasms,Breast Malignant Tumor,Breast Malignant Tumors,Breast Neoplasm,Breast Tumor,Cancer, Breast,Cancer, Mammary,Cancers, Mammary,Carcinoma, Breast,Carcinoma, Human Mammary,Carcinomas, Breast,Carcinomas, Human Mammary,Human Mammary Carcinomas,Human Mammary Neoplasm,Human Mammary Neoplasms,Mammary Cancers,Mammary Carcinomas, Human,Neoplasm, Breast,Neoplasm, Human Mammary,Neoplasms, Human Mammary,Tumor, Breast
D004359 Drug Therapy, Combination Therapy with two or more separate preparations given for a combined effect. Combination Chemotherapy,Polychemotherapy,Chemotherapy, Combination,Combination Drug Therapy,Drug Polytherapy,Therapy, Combination Drug,Chemotherapies, Combination,Combination Chemotherapies,Combination Drug Therapies,Drug Polytherapies,Drug Therapies, Combination,Polychemotherapies,Polytherapies, Drug,Polytherapy, Drug,Therapies, Combination Drug
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000970 Antineoplastic Agents Substances that inhibit or prevent the proliferation of NEOPLASMS. Anticancer Agent,Antineoplastic,Antineoplastic Agent,Antineoplastic Drug,Antitumor Agent,Antitumor Drug,Cancer Chemotherapy Agent,Cancer Chemotherapy Drug,Anticancer Agents,Antineoplastic Drugs,Antineoplastics,Antitumor Agents,Antitumor Drugs,Cancer Chemotherapy Agents,Cancer Chemotherapy Drugs,Chemotherapeutic Anticancer Agents,Chemotherapeutic Anticancer Drug,Agent, Anticancer,Agent, Antineoplastic,Agent, Antitumor,Agent, Cancer Chemotherapy,Agents, Anticancer,Agents, Antineoplastic,Agents, Antitumor,Agents, Cancer Chemotherapy,Agents, Chemotherapeutic Anticancer,Chemotherapy Agent, Cancer,Chemotherapy Agents, Cancer,Chemotherapy Drug, Cancer,Chemotherapy Drugs, Cancer,Drug, Antineoplastic,Drug, Antitumor,Drug, Cancer Chemotherapy,Drug, Chemotherapeutic Anticancer,Drugs, Antineoplastic,Drugs, Antitumor,Drugs, Cancer Chemotherapy
D013936 Thymidine A nucleoside in which THYMINE is linked to DEOXYRIBOSE. 2'-Deoxythymidine,Deoxythymidine,2' Deoxythymidine
D014316 Tritium The radioactive isotope of hydrogen also known as hydrogen-3. It contains two NEUTRONS and one PROTON in its nucleus and decays to produce low energy BETA PARTICLES. Hydrogen-3,Hydrogen 3

Related Publications

A Sulkes, and R B Livingston, and W K Murphy
Tritiated thymidine labeling index of benign and malignant human breast epithelium.
January 1976, Journal of surgical oncology,
A Sulkes, and R B Livingston, and W K Murphy
Significance of the Tritiated Thymidine Labeling Index in breast cancers.
March 1985, The Japanese journal of surgery,
A Sulkes, and R B Livingston, and W K Murphy
Estrogen receptor heterogeneity and the relationship between estrogen receptor and the tritiated thymidine labeling index in human breast cancer.
January 1982, Oncology,
A Sulkes, and R B Livingston, and W K Murphy
Thymidine labeling index: prognostic role in breast cancer.
August 2004, American journal of clinical oncology,
A Sulkes, and R B Livingston, and W K Murphy
LABELING OF HUMAN TUMORS WITH TRITIATED THYMIDINE.
March 1965, Archives of pathology,
A Sulkes, and R B Livingston, and W K Murphy
Tritiated thymidine labeling index in Indian childhood acute lymphoblastic leukemia.
January 1987, Leukemia research,
A Sulkes, and R B Livingston, and W K Murphy
Thymidine labeling index in breast tumors.
March 1990, The Japanese journal of surgery,
A Sulkes, and R B Livingston, and W K Murphy
Measurement of tritiated thymidine labeling index by incubation in vitro of surgically removed cervical cancer.
June 1977, Gan,
A Sulkes, and R B Livingston, and W K Murphy
Labeling of human tumor cells in vivo by tritiated thymidine.
January 1960, Laboratory investigation; a journal of technical methods and pathology,
A Sulkes, and R B Livingston, and W K Murphy
Thymidine labeling index and estrogen receptor level in 64 human breast cancers.
December 1979, Biomedicine / [publiee pour l'A.A.I.C.I.G.],
Copied contents to your clipboard!