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Secretin and glucagon potentiate glucose-induced insulin release. We have compared the effects of secretin and glucagon with that of four hybrid molecules of the two hormones on insulin release and formation of cyclic AMP (cAMP) in isolated mouse pancreatic islets. All six peptides potentiated the release of insulin at 10 mM D-glucose, and their effects were indistinguishable with respect to the dynamics of release, dose-response relationship, and glucose dependency. However, measurements of cAMP accumulation in the presence of the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (10(-4) M) showed that the fold increase compared with glucose alone had the following ranking order: secretin = [Tyr10, Tyr13]-secretin 1.6 less than [Tyr10, Tyr13, Trp25]secretin 1.8 less than glucagon 1.9 less than [Asp3, Glu9, Arg12]glucagon 2.3 = [Asp3, Glu9]glucagon. These results suggest that despite similar potentiating effects of secretin and glucagon on glucose-induced insulin release, their modes of action may be different.
H Kofod, and
D Andreu, and
P Thams, and
R B Merrifield, and
C J Hedeskov, and
B Hansen, and
A Lernmark
April 1967,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
H Kofod, and
D Andreu, and
P Thams, and
R B Merrifield, and
C J Hedeskov, and
B Hansen, and
A Lernmark
March 1967,
Nordisk medicin,
H Kofod, and
D Andreu, and
P Thams, and
R B Merrifield, and
C J Hedeskov, and
B Hansen, and
A Lernmark
April 1968,
Acta endocrinologica,
H Kofod, and
D Andreu, and
P Thams, and
R B Merrifield, and
C J Hedeskov, and
B Hansen, and
A Lernmark
July 1972,
The Journal of clinical endocrinology and metabolism,
H Kofod, and
D Andreu, and
P Thams, and
R B Merrifield, and
C J Hedeskov, and
B Hansen, and
A Lernmark
December 1988,
Regulatory peptides,
H Kofod, and
D Andreu, and
P Thams, and
R B Merrifield, and
C J Hedeskov, and
B Hansen, and
A Lernmark
November 2002,
Digestive diseases and sciences,
H Kofod, and
D Andreu, and
P Thams, and
R B Merrifield, and
C J Hedeskov, and
B Hansen, and
A Lernmark
January 1976,
Surgical forum,
H Kofod, and
D Andreu, and
P Thams, and
R B Merrifield, and
C J Hedeskov, and
B Hansen, and
A Lernmark
June 1978,
The Journal of clinical endocrinology and metabolism,
H Kofod, and
D Andreu, and
P Thams, and
R B Merrifield, and
C J Hedeskov, and
B Hansen, and
A Lernmark
October 1978,
Endocrinologia japonica,
H Kofod, and
D Andreu, and
P Thams, and
R B Merrifield, and
C J Hedeskov, and
B Hansen, and
A Lernmark
April 1976,
Lancet (London, England),
