-transparent.png){kind=logo}
The relation of plasma levels of atrial natriuretic peptide (ANP) to those of cyclic 3', 5'-guanosine monophosphate (cGMP) was studied in 43 patients with various heart diseases. Plasma levels of both ANP and cGMP were significantly (p less than 0.001) elevated in 34 patients with chronic heart diseases, and a significant positive correlation was observed between the two variables (r = 0.706, p less than 0.01). Clinical improvement of congestive heart failure resulted in a concomitant decrease in plasma ANP and cGMP levels in 6 patients. In 3 patients with paroxysmal atrial fibrillation, plasma levels of ANP and cGMP increased markedly during arrhythmia. These results indicate that increased circulating ANP may stimulate cGMP production in target cells, which in turn raises plasma levels of cGMP in humans.
H Nakaoka, and
K Imataka, and
Y Kitahara, and
J Fujii, and
M Ishibashi, and
T Yamaji
June 1987,
The Journal of laboratory and clinical medicine,
H Nakaoka, and
K Imataka, and
Y Kitahara, and
J Fujii, and
M Ishibashi, and
T Yamaji
June 1992,
Journal of the American Society of Nephrology : JASN,
H Nakaoka, and
K Imataka, and
Y Kitahara, and
J Fujii, and
M Ishibashi, and
T Yamaji
March 1997,
Journal of gastroenterology and hepatology,
H Nakaoka, and
K Imataka, and
Y Kitahara, and
J Fujii, and
M Ishibashi, and
T Yamaji
October 1987,
Pediatrics,
H Nakaoka, and
K Imataka, and
Y Kitahara, and
J Fujii, and
M Ishibashi, and
T Yamaji
February 1993,
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies,
H Nakaoka, and
K Imataka, and
Y Kitahara, and
J Fujii, and
M Ishibashi, and
T Yamaji
January 2003,
Polskie Archiwum Medycyny Wewnetrznej,
H Nakaoka, and
K Imataka, and
Y Kitahara, and
J Fujii, and
M Ishibashi, and
T Yamaji
August 1991,
European heart journal,
H Nakaoka, and
K Imataka, and
Y Kitahara, and
J Fujii, and
M Ishibashi, and
T Yamaji
September 1991,
Clinica chimica acta; international journal of clinical chemistry,
H Nakaoka, and
K Imataka, and
Y Kitahara, and
J Fujii, and
M Ishibashi, and
T Yamaji
April 1989,
Journal of hypertension,
H Nakaoka, and
K Imataka, and
Y Kitahara, and
J Fujii, and
M Ishibashi, and
T Yamaji
October 1995,
The American journal of the medical sciences,
