BIOMAT Database Logo BIOMAT Database Logo

Concordance between upper and lower airway microbiota in infants with cystic fibrosis. 2017

Sabine M P J Prevaes, and Wouter A A de Steenhuijsen Piters, and Karin M de Winter-de Groot, and Hettie M Janssens, and Gerdien A Tramper-Stranders, and Mei Ling J N Chu, and Harm A Tiddens, and Mireille van Westreenen, and Cornelis K van der Ent, and Elisabeth A M Sanders, and Debby Bogaert
Dept of Paediatrics, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, The Netherlands.

Nasopharyngeal and oropharyngeal samples are commonly used to direct therapy for lower respiratory tract infections in non-expectorating infants with cystic fibrosis (CF).We aimed to investigate the concordance between the bacterial community compositions of 25 sets of nasopharyngeal, oropharyngeal and bronchoalveolar lavage (BAL) samples from 17 infants with CF aged ∼5 months (n=13) and ∼12 months (n=12) using conventional culturing and 16S-rRNA sequencing.Clustering analyses demonstrated that BAL microbiota profiles were in general characterised by a mixture of oral and nasopharyngeal bacteria, including commensals like Streptococcus, Neisseria, Veillonella and Rothia spp. and potential pathogens like Staphylococcus aureus, Haemophilus influenzae and Moraxella spp. Within each individual, however, the degree of concordance differed between microbiota of both upper respiratory tract niches and the corresponding BAL.The inconsistent intra-individual concordance between microbiota of the upper and lower respiratory niches suggests that the lungs of infants with CF may have their own microbiome that seems seeded by, but is not identical to, the upper respiratory tract microbiome.

UI MeSH Term Description Entries

Related Publications

Sabine M P J Prevaes, and Wouter A A de Steenhuijsen Piters, and Karin M de Winter-de Groot, and Hettie M Janssens, and Gerdien A Tramper-Stranders, and Mei Ling J N Chu, and Harm A Tiddens, and Mireille van Westreenen, and Cornelis K van der Ent, and Elisabeth A M Sanders, and Debby Bogaert
Concordance between upper and lower airway microbiota in children with cystic fibrosis.
September 2025, Journal of medical microbiology,
Sabine M P J Prevaes, and Wouter A A de Steenhuijsen Piters, and Karin M de Winter-de Groot, and Hettie M Janssens, and Gerdien A Tramper-Stranders, and Mei Ling J N Chu, and Harm A Tiddens, and Mireille van Westreenen, and Cornelis K van der Ent, and Elisabeth A M Sanders, and Debby Bogaert
Differences in the lower airway microbiota of infants with and without cystic fibrosis.
September 2019, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society,
Sabine M P J Prevaes, and Wouter A A de Steenhuijsen Piters, and Karin M de Winter-de Groot, and Hettie M Janssens, and Gerdien A Tramper-Stranders, and Mei Ling J N Chu, and Harm A Tiddens, and Mireille van Westreenen, and Cornelis K van der Ent, and Elisabeth A M Sanders, and Debby Bogaert
Upper airway microbiota development in infants with cystic fibrosis diagnosed by newborn screen.
July 2023, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society,
Sabine M P J Prevaes, and Wouter A A de Steenhuijsen Piters, and Karin M de Winter-de Groot, and Hettie M Janssens, and Gerdien A Tramper-Stranders, and Mei Ling J N Chu, and Harm A Tiddens, and Mireille van Westreenen, and Cornelis K van der Ent, and Elisabeth A M Sanders, and Debby Bogaert
Upper and lower airway microbiology in cystic fibrosis.
March 2010, Thorax,
Sabine M P J Prevaes, and Wouter A A de Steenhuijsen Piters, and Karin M de Winter-de Groot, and Hettie M Janssens, and Gerdien A Tramper-Stranders, and Mei Ling J N Chu, and Harm A Tiddens, and Mireille van Westreenen, and Cornelis K van der Ent, and Elisabeth A M Sanders, and Debby Bogaert
The Cystic Fibrosis Upper and Lower Airway Metagenome.
March 2023, Microbiology spectrum,
Sabine M P J Prevaes, and Wouter A A de Steenhuijsen Piters, and Karin M de Winter-de Groot, and Hettie M Janssens, and Gerdien A Tramper-Stranders, and Mei Ling J N Chu, and Harm A Tiddens, and Mireille van Westreenen, and Cornelis K van der Ent, and Elisabeth A M Sanders, and Debby Bogaert
Lower airway inflammation in infants and young children with cystic fibrosis.
October 1997, American journal of respiratory and critical care medicine,
Sabine M P J Prevaes, and Wouter A A de Steenhuijsen Piters, and Karin M de Winter-de Groot, and Hettie M Janssens, and Gerdien A Tramper-Stranders, and Mei Ling J N Chu, and Harm A Tiddens, and Mireille van Westreenen, and Cornelis K van der Ent, and Elisabeth A M Sanders, and Debby Bogaert
Longitudinal development of the airway microbiota in infants with cystic fibrosis.
March 2019, Scientific reports,
Sabine M P J Prevaes, and Wouter A A de Steenhuijsen Piters, and Karin M de Winter-de Groot, and Hettie M Janssens, and Gerdien A Tramper-Stranders, and Mei Ling J N Chu, and Harm A Tiddens, and Mireille van Westreenen, and Cornelis K van der Ent, and Elisabeth A M Sanders, and Debby Bogaert
Protease-antiprotease imbalances differ between Cystic Fibrosis patients' upper and lower airway secretions.
May 2015, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society,
Sabine M P J Prevaes, and Wouter A A de Steenhuijsen Piters, and Karin M de Winter-de Groot, and Hettie M Janssens, and Gerdien A Tramper-Stranders, and Mei Ling J N Chu, and Harm A Tiddens, and Mireille van Westreenen, and Cornelis K van der Ent, and Elisabeth A M Sanders, and Debby Bogaert
Reemergence of Lower-Airway Microbiota in Lung Transplant Patients with Cystic Fibrosis.
December 2016, Annals of the American Thoracic Society,
Sabine M P J Prevaes, and Wouter A A de Steenhuijsen Piters, and Karin M de Winter-de Groot, and Hettie M Janssens, and Gerdien A Tramper-Stranders, and Mei Ling J N Chu, and Harm A Tiddens, and Mireille van Westreenen, and Cornelis K van der Ent, and Elisabeth A M Sanders, and Debby Bogaert
The microbiology of the cystic fibrosis upper and lower airway.
November 2015, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society,
Copied contents to your clipboard!