Reinforced collagen with oxidized microcrystalline cellulose shows improved hemostatic effects. 2017

Hui Li, and Weilu Cheng, and Ke Liu, and Lei Chen, and Yudong Huang, and Xiaofeng Wang, and Zhiyong Lv, and Jinmei He, and Cheng Li
Department of Oral and Maxillofacial Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150001, China. Electronic address: lihui881635@163.com.

Sponges composed of different levels of composite collagen/oxidized microcrystalline cellulose (collagen/OMCC), denoted M1-M4, were studied to improve the hemostatic effect of single-collagen sponges. Surface morphological observations showed that structural combinations and intermolecular interactions occurred between collagen and OMCC in the composites. M2 presented the best physical properties and platelet activation and was thus selected for the investigations of the in vitro coagulation time and hemostatic and biological effects on animals. The results illustrated that M2 could reduce the length of the activated partial thromboplastin time (APTT) and thrombin time (TT) and presented rapid hemostatic efficiency in the two injury models (P<0.05). These findings were used to evaluate the hemostatic mechanism of M2, which can promote blood absorption and platelet activation and could be directly involved in the intrinsic coagulation pathway to accelerate hemostasis. Furthermore, M2 was not cytotoxic and was completely biodegraded in subcutaneous tissue within 28days.

UI MeSH Term Description Entries
D010314 Partial Thromboplastin Time The time required for the appearance of FIBRIN strands following the mixing of PLASMA with phospholipid platelet substitute (e.g., crude cephalins, soybean phosphatides). It is a test of the intrinsic pathway (factors VIII, IX, XI, and XII) and the common pathway (fibrinogen, prothrombin, factors V and X) of BLOOD COAGULATION. It is used as a screening test and to monitor HEPARIN therapy. Activated Partial Thromboplastin Time,Cephalin-Kaolin Coagulation Time,Kaolin-Cephalin Coagulation Time,Thromboplastin Time, Partial,Coagulation Time, Cephalin-Kaolin,Cephalin Kaolin Coagulation Time,Coagulation Time, Cephalin Kaolin,Coagulation Time, Kaolin-Cephalin,Kaolin Cephalin Coagulation Time
D011817 Rabbits A burrowing plant-eating mammal with hind limbs that are longer than its fore limbs. It belongs to the family Leporidae of the order Lagomorpha, and in contrast to hares, possesses 22 instead of 24 pairs of chromosomes. Belgian Hare,New Zealand Rabbit,New Zealand Rabbits,New Zealand White Rabbit,Rabbit,Rabbit, Domestic,Chinchilla Rabbits,NZW Rabbits,New Zealand White Rabbits,Oryctolagus cuniculus,Chinchilla Rabbit,Domestic Rabbit,Domestic Rabbits,Hare, Belgian,NZW Rabbit,Rabbit, Chinchilla,Rabbit, NZW,Rabbit, New Zealand,Rabbits, Chinchilla,Rabbits, Domestic,Rabbits, NZW,Rabbits, New Zealand,Zealand Rabbit, New,Zealand Rabbits, New,cuniculus, Oryctolagus
D001777 Blood Coagulation The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot. Blood Clotting,Coagulation, Blood,Blood Clottings,Clotting, Blood
D002482 Cellulose A polysaccharide with glucose units linked as in CELLOBIOSE. It is the chief constituent of plant fibers, cotton being the purest natural form of the substance. As a raw material, it forms the basis for many derivatives used in chromatography, ion exchange materials, explosives manufacturing, and pharmaceutical preparations. Alphacel,Avicel,Heweten,Polyanhydroglucuronic Acid,Rayophane,Sulfite Cellulose,alpha-Cellulose,Acid, Polyanhydroglucuronic,alpha Cellulose
D002483 Cellulose, Oxidized A cellulose of varied carboxyl content retaining the fibrous structure. It is commonly used as a local hemostatic and as a matrix for normal blood coagulation. Absorbable Cellulose,Carboxycellulose,Cellulosic Acid,Oxycel,Oxycellulose,Cellulose, Absorbable,Oxidized Cellulose
D003094 Collagen A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH). Avicon,Avitene,Collagen Felt,Collagen Fleece,Collagenfleece,Collastat,Dermodress,Microfibril Collagen Hemostat,Pangen,Zyderm,alpha-Collagen,Collagen Hemostat, Microfibril,alpha Collagen
D006487 Hemostasis The process which spontaneously arrests the flow of BLOOD from vessels carrying blood under pressure. It is accomplished by contraction of the vessels, adhesion and aggregation of formed blood elements (eg. ERYTHROCYTE AGGREGATION), and the process of BLOOD COAGULATION. Hemostases
D006490 Hemostatics Agents acting to arrest the flow of blood. Absorbable hemostatics arrest bleeding either by the formation of an artificial clot or by providing a mechanical matrix that facilitates clotting when applied directly to the bleeding surface. These agents function more at the capillary level and are not effective at stemming arterial or venous bleeding under any significant intravascular pressure. Antihemorrhagic,Hemostatic,Antihemorrhagics
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

Hui Li, and Weilu Cheng, and Ke Liu, and Lei Chen, and Yudong Huang, and Xiaofeng Wang, and Zhiyong Lv, and Jinmei He, and Cheng Li
January 2008, Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti,
Hui Li, and Weilu Cheng, and Ke Liu, and Lei Chen, and Yudong Huang, and Xiaofeng Wang, and Zhiyong Lv, and Jinmei He, and Cheng Li
December 1978, The Journal of the American Osteopathic Association,
Hui Li, and Weilu Cheng, and Ke Liu, and Lei Chen, and Yudong Huang, and Xiaofeng Wang, and Zhiyong Lv, and Jinmei He, and Cheng Li
September 1970, American journal of surgery,
Hui Li, and Weilu Cheng, and Ke Liu, and Lei Chen, and Yudong Huang, and Xiaofeng Wang, and Zhiyong Lv, and Jinmei He, and Cheng Li
March 1974, Surgical neurology,
Hui Li, and Weilu Cheng, and Ke Liu, and Lei Chen, and Yudong Huang, and Xiaofeng Wang, and Zhiyong Lv, and Jinmei He, and Cheng Li
February 2020, Carbohydrate polymers,
Hui Li, and Weilu Cheng, and Ke Liu, and Lei Chen, and Yudong Huang, and Xiaofeng Wang, and Zhiyong Lv, and Jinmei He, and Cheng Li
April 2021, Heliyon,
Hui Li, and Weilu Cheng, and Ke Liu, and Lei Chen, and Yudong Huang, and Xiaofeng Wang, and Zhiyong Lv, and Jinmei He, and Cheng Li
May 2018, Journal of materials science. Materials in medicine,
Hui Li, and Weilu Cheng, and Ke Liu, and Lei Chen, and Yudong Huang, and Xiaofeng Wang, and Zhiyong Lv, and Jinmei He, and Cheng Li
November 2016, Polymers,
Hui Li, and Weilu Cheng, and Ke Liu, and Lei Chen, and Yudong Huang, and Xiaofeng Wang, and Zhiyong Lv, and Jinmei He, and Cheng Li
September 2016, Carbohydrate polymers,
Hui Li, and Weilu Cheng, and Ke Liu, and Lei Chen, and Yudong Huang, and Xiaofeng Wang, and Zhiyong Lv, and Jinmei He, and Cheng Li
June 1949, Virginia medical monthly,
Copied contents to your clipboard!