Biomaterial Database

Turkey herpesvirus. VII. The evolution of Marek's disease in chickens vaccinated at one day of age and challenged at different periods of time after vaccination. 1988

I V Pătraşcu, and B V Calnek, and M Smith

Stefan S. Nicolau Institute of Virology, Bucharest, Romania.

The Single Comb White Leghorn, the Cornell S strain chickens vaccinated at one day of age with cell free Herpesvirus of turkey (HVT) 100 and 1000 focus forming-units (FFU) per bird were raised in isolatores. At different periods of time the vaccinated and control chickens were reared together with chickens with clinical symptoms of Marek's disease previously inoculated with JM-Strain of Marek's disease virus (MDV) in a separate isolation room throughout the experiment. The specific protective effect was 84.6-100 percent in vaccinated chickens raised together with chickens with MD, soon or 4, 7, 11, 14, 17 and 21 days after vaccination. The period of MD evolution, Mean Time to Death (MTD) at unvaccinated chickens was 54.8 and at vaccinated chickens with 100 and 1000 FFU of HVT per bird, MTD was 65.9 and 78.5 days respectively. Rhode Island Red (RIR-HPRS) and Brown Leghorn (BrL-HPRS) chickens vaccinated at one day of age with cell-free HVT 100 and 1000 FFU per bird were raised in isolation rooms. At 21 day of age vaccinated and unvaccinated chickens were challenged with MDV strain P-501 and reared together in isolation rooms throughout the experiments. The specific protective effect was 71.6-100 percent and 76.8-100 percent at vaccinated RIR-HPRS and BrL-HPRS respectively. Mean time to death was 58-68.5 and 95 days at RIR-HPRS vaccinated chickens with 100 and 1000 FFU of HVT respectively and 38.1-48.25 days at control group. MTD was 72.5-87 days at BrL-HPRS chickens vaccinated with 100 FFU of HVT and 41.5-50.25 days at control group.

UI	MeSH Term	Description	Entries
D007114	Immunization	Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).	Immunologic Stimulation,Immunostimulation,Sensitization, Immunologic,Variolation,Immunologic Sensitization,Immunological Stimulation,Sensitization, Immunological,Stimulation, Immunologic,Immunizations,Immunological Sensitization,Immunological Sensitizations,Immunological Stimulations,Sensitizations, Immunological,Stimulation, Immunological,Stimulations, Immunological,Variolations
D008380	Marek Disease	A transmissible viral disease of birds caused by avian herpesvirus 2 (HERPESVIRUS 2, GALLID) and other MARDIVIRUS. There is lymphoid cell infiltration or lymphomatous tumor formation in the peripheral nerves and gonads, but may also involve visceral organs, skin, muscle, and the eye.	Fowl Paralysis,Marek's Disease,Fowl Paralyses,Mareks Disease,Paralyses, Fowl,Paralysis, Fowl
D008381	Herpesvirus 2, Gallid	The type species of the genus MARDIVIRUS in the family HERPESVIRIDAE. It is the etiologic agent of MAREK DISEASE, infecting domestic fowl and wild birds.	Fowl Paralysis Virus,Marek's Disease Herpesvirus 1,Marek's Disease Virus Serotype 1,Neurolymphomatosis Virus,Gallid Herpesvirus 2,Herpesvirus 2 (gamma), Gallid,Marek Disease Herpesvirus 1,Fowl Paralysis Viruses,Neurolymphomatosis Viruses,Paralysis Virus, Fowl,Paralysis Viruses, Fowl
D002645	Chickens	Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.	Gallus gallus,Gallus domesticus,Gallus gallus domesticus,Chicken
D004306	Dose-Response Relationship, Immunologic	A specific immune response elicited by a specific dose of an immunologically active substance or cell in an organism, tissue, or cell.	Immunologic Dose-Response Relationship,Relationship, Immunologic Dose-Response,Dose Response Relationship, Immunologic,Dose-Response Relationships, Immunologic,Immunologic Dose Response Relationship,Immunologic Dose-Response Relationships,Relationship, Immunologic Dose Response,Relationships, Immunologic Dose-Response
D004353	Drug Evaluation, Preclinical	Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.	Drug Screening,Evaluation Studies, Drug, Pre-Clinical,Drug Evaluation Studies, Preclinical,Drug Evaluations, Preclinical,Evaluation Studies, Drug, Preclinical,Evaluation, Preclinical Drug,Evaluations, Preclinical Drug,Medicinal Plants Testing, Preclinical,Preclinical Drug Evaluation,Preclinical Drug Evaluations,Drug Screenings,Screening, Drug,Screenings, Drug
D006564	Herpesviridae	A family of enveloped, linear, double-stranded DNA viruses infecting a wide variety of animals. Subfamilies, based on biological characteristics, include: ALPHAHERPESVIRINAE; BETAHERPESVIRINAE; and GAMMAHERPESVIRINAE.	Mouse Thymic Virus,Murid herpesvirus 3,Thymic Group Viruses,Herpesviruses,Mouse Thymic Viruses,Thymic Virus, Mouse,Thymic Viruses, Mouse
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000914	Antibodies, Viral	Immunoglobulins produced in response to VIRAL ANTIGENS.	Viral Antibodies
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor