Biomaterial Database

Genetic studies on toxic shock syndrome toxin-1 (TSST-1) producing Staphylococcus aureus strains from Austria, the USA and West Germany. 1988

N Dickgiesser

Institut für Hygiene und Medizinische Mikrobiologie der Fakultät für Klinische Medizin, Mannheim der Universität Heidelberg.

DNA preparations obtained from 10 different toxic shock syndrome toxin-1 positive S. aureus strains from Austria, the USA and West Germany were examined in respect of their homology to the TSST-1 gene of pRN6101. Whole cell DNA was digested with HpaII or EcoRI, separated on agarose gels and transferred to nitrocellulose; furthermore the dotblot procedure was used. The radioactively labelled gene probe used was the 300 bp BamHI-HindII fragment of the TSST-1 gene region of pRN6101. All S. aureus strains had homology with this fragment. Homology was located on fragments of different molecular size. Therefore it is concluded that the TSST-1 DNA fragment has different locations in the chromosome of different S. aureus strains.

UI	MeSH Term	Description	Entries
D004262	DNA Restriction Enzymes	Enzymes that are part of the restriction-modification systems. They catalyze the endonucleolytic cleavage of DNA sequences which lack the species-specific methylation pattern in the host cell's DNA. Cleavage yields random or specific double-stranded fragments with terminal 5'-phosphates. The function of restriction enzymes is to destroy any foreign DNA that invades the host cell. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms. They are also used as tools for the systematic dissection and mapping of chromosomes, in the determination of base sequences of DNAs, and have made it possible to splice and recombine genes from one organism into the genome of another. EC 3.21.1.	Restriction Endonucleases,DNA Restriction Enzyme,Restriction Endonuclease,Endonuclease, Restriction,Endonucleases, Restriction,Enzymes, DNA Restriction,Restriction Enzyme, DNA,Restriction Enzymes, DNA
D004269	DNA, Bacterial	Deoxyribonucleic acid that makes up the genetic material of bacteria.	Bacterial DNA
D004768	Enterotoxins	Substances that are toxic to the intestinal tract causing vomiting, diarrhea, etc.; most common enterotoxins are produced by bacteria.	Staphylococcal Enterotoxin,Enterotoxin,Staphylococcal Enterotoxins,Enterotoxin, Staphylococcal,Enterotoxins, Staphylococcal
D005860	Germany, West	The former Federal Republic of Germany which was reunified with the former German Democratic Republic in 1990.	Federal Republic of Germany,Germany, Federal Republic of
D001317	Austria	A country located in Central Europe, north of Italy and Slovenia. The capital is Vienna.
D001427	Bacterial Toxins	Toxic substances formed in or elaborated by bacteria; they are usually proteins with high molecular weight and antigenicity; some are used as antibiotics and some to skin test for the presence of or susceptibility to certain diseases.	Bacterial Toxin,Toxins, Bacterial,Toxin, Bacterial
D012689	Sequence Homology, Nucleic Acid	The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.	Base Sequence Homology,Homologous Sequences, Nucleic Acid,Homologs, Nucleic Acid Sequence,Homology, Base Sequence,Homology, Nucleic Acid Sequence,Nucleic Acid Sequence Homologs,Nucleic Acid Sequence Homology,Sequence Homology, Base,Base Sequence Homologies,Homologies, Base Sequence,Sequence Homologies, Base
D013045	Species Specificity	The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.	Species Specificities,Specificities, Species,Specificity, Species
D013211	Staphylococcus aureus	Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.
D014481	United States	A country in NORTH AMERICA between CANADA and MEXICO.

Related Publications

N Dickgiesser

Prevalence of toxic shock syndrome toxin 1 (TSST-1)-producing strains of Staphylococcus aureus and antibody to TSST-1 among healthy Japanese women.

August 2008, Journal of clinical microbiology,

N Dickgiesser

Production of toxic shock syndrome toxin-1 (TSST-1) by Staphylococcus aureus strains isolated from humans, animals and foods in Nigeria.

April 1992, Microbiologica,

N Dickgiesser

[Evidence of enterotoxins and toxic shock syndrome toxin (TSST-1) in strains of Staphylococcus aureus isolated from various biological materials].

August 2002, Epidemiologie, mikrobiologie, imunologie : casopis Spolecnosti pro epidemiologii a mikrobiologii Ceske lekarske spolecnosti J.E. Purkyne,

N Dickgiesser

Occurrence of toxic shock syndrome toxin-1 producing Staphylococcus aureus and the anti TSST-1 serostatus of hospital personnel in Nigeria.

July 1991, East African medical journal,

N Dickgiesser

Production of toxic shock syndrome toxin-1 (TSST-1) associated with Staphylococcus aureus from a pyogenic skin infection.

January 1988, Acta microbiologica Hungarica,

N Dickgiesser

Toxic shock syndrome toxin-1 (TSST-1) production and phage susceptibility of Staphylococcus aureus strains from human vaginas and anterior nares in Trinidad.

January 1994, Zentralblatt fur Bakteriologie : international journal of medical microbiology,

N Dickgiesser

Toxin exposure and HLA alleles determine serum antibody binding to toxic shock syndrome toxin 1 (TSST-1) of Staphylococcus aureus.

January 2023, Frontiers in immunology,