-transparent.png){kind=logo}
Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics. 2017
Jill M Pulley, and
Jana K Shirey-Rice, and
Robert R Lavieri, and
Rebecca N Jerome, and
Nicole M Zaleski, and
David M Aronoff, and
Lisa Bastarache, and
Xinnan Niu, and
Kenneth J Holroyd, and
Dan M Roden, and
Eric P Skaar, and
Colleen M Niswender, and
Lawrence J Marnett, and
Craig W Lindsley, and
Leeland B Ekstrom, and
Alan R Bentley, and
Gordon R Bernard, and
Charles C Hong, and
Joshua C Denny
1 Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center , Nashville, Tennessee.
The potential impact of using human genetic data linked to longitudinal electronic medical records on drug development is extraordinary; however, the practical application of these data necessitates some organizational innovations. Vanderbilt has created resources such as an easily queried database of >2.6 million de-identified electronic health records linked to BioVU, which is a DNA biobank with more than 230,000 unique samples. To ensure these data are used to maximally benefit and accelerate both de novo drug discovery and drug repurposing efforts, we created the Accelerating Drug Development and Repurposing Incubator, a multidisciplinary think tank of experts in various therapeutic areas within both basic and clinical science as well as experts in legal, business, and other operational domains. The Incubator supports a diverse pipeline of drug indication finding projects, leveraging the natural experiment of human genetics.
Related Publications
Jill M Pulley, and
Jana K Shirey-Rice, and
Robert R Lavieri, and
Rebecca N Jerome, and
Nicole M Zaleski, and
David M Aronoff, and
Lisa Bastarache, and
Xinnan Niu, and
Kenneth J Holroyd, and
Dan M Roden, and
Eric P Skaar, and
Colleen M Niswender, and
Lawrence J Marnett, and
Craig W Lindsley, and
Leeland B Ekstrom, and
Alan R Bentley, and
Gordon R Bernard, and
Charles C Hong, and
Joshua C Denny
December 2018,
JCO clinical cancer informatics,
Jill M Pulley, and
Jana K Shirey-Rice, and
Robert R Lavieri, and
Rebecca N Jerome, and
Nicole M Zaleski, and
David M Aronoff, and
Lisa Bastarache, and
Xinnan Niu, and
Kenneth J Holroyd, and
Dan M Roden, and
Eric P Skaar, and
Colleen M Niswender, and
Lawrence J Marnett, and
Craig W Lindsley, and
Leeland B Ekstrom, and
Alan R Bentley, and
Gordon R Bernard, and
Charles C Hong, and
Joshua C Denny
November 2022,
Life sciences in space research,
Jill M Pulley, and
Jana K Shirey-Rice, and
Robert R Lavieri, and
Rebecca N Jerome, and
Nicole M Zaleski, and
David M Aronoff, and
Lisa Bastarache, and
Xinnan Niu, and
Kenneth J Holroyd, and
Dan M Roden, and
Eric P Skaar, and
Colleen M Niswender, and
Lawrence J Marnett, and
Craig W Lindsley, and
Leeland B Ekstrom, and
Alan R Bentley, and
Gordon R Bernard, and
Charles C Hong, and
Joshua C Denny
July 2017,
Trends in cardiovascular medicine,
Jill M Pulley, and
Jana K Shirey-Rice, and
Robert R Lavieri, and
Rebecca N Jerome, and
Nicole M Zaleski, and
David M Aronoff, and
Lisa Bastarache, and
Xinnan Niu, and
Kenneth J Holroyd, and
Dan M Roden, and
Eric P Skaar, and
Colleen M Niswender, and
Lawrence J Marnett, and
Craig W Lindsley, and
Leeland B Ekstrom, and
Alan R Bentley, and
Gordon R Bernard, and
Charles C Hong, and
Joshua C Denny
August 2023,
Addiction biology,
Jill M Pulley, and
Jana K Shirey-Rice, and
Robert R Lavieri, and
Rebecca N Jerome, and
Nicole M Zaleski, and
David M Aronoff, and
Lisa Bastarache, and
Xinnan Niu, and
Kenneth J Holroyd, and
Dan M Roden, and
Eric P Skaar, and
Colleen M Niswender, and
Lawrence J Marnett, and
Craig W Lindsley, and
Leeland B Ekstrom, and
Alan R Bentley, and
Gordon R Bernard, and
Charles C Hong, and
Joshua C Denny
April 2020,
Current opinion in pharmacology,
Jill M Pulley, and
Jana K Shirey-Rice, and
Robert R Lavieri, and
Rebecca N Jerome, and
Nicole M Zaleski, and
David M Aronoff, and
Lisa Bastarache, and
Xinnan Niu, and
Kenneth J Holroyd, and
Dan M Roden, and
Eric P Skaar, and
Colleen M Niswender, and
Lawrence J Marnett, and
Craig W Lindsley, and
Leeland B Ekstrom, and
Alan R Bentley, and
Gordon R Bernard, and
Charles C Hong, and
Joshua C Denny
July 2022,
Cancer discovery,
Jill M Pulley, and
Jana K Shirey-Rice, and
Robert R Lavieri, and
Rebecca N Jerome, and
Nicole M Zaleski, and
David M Aronoff, and
Lisa Bastarache, and
Xinnan Niu, and
Kenneth J Holroyd, and
Dan M Roden, and
Eric P Skaar, and
Colleen M Niswender, and
Lawrence J Marnett, and
Craig W Lindsley, and
Leeland B Ekstrom, and
Alan R Bentley, and
Gordon R Bernard, and
Charles C Hong, and
Joshua C Denny
March 2019,
The New England journal of medicine,
Jill M Pulley, and
Jana K Shirey-Rice, and
Robert R Lavieri, and
Rebecca N Jerome, and
Nicole M Zaleski, and
David M Aronoff, and
Lisa Bastarache, and
Xinnan Niu, and
Kenneth J Holroyd, and
Dan M Roden, and
Eric P Skaar, and
Colleen M Niswender, and
Lawrence J Marnett, and
Craig W Lindsley, and
Leeland B Ekstrom, and
Alan R Bentley, and
Gordon R Bernard, and
Charles C Hong, and
Joshua C Denny
January 2021,
Advances in experimental medicine and biology,
Jill M Pulley, and
Jana K Shirey-Rice, and
Robert R Lavieri, and
Rebecca N Jerome, and
Nicole M Zaleski, and
David M Aronoff, and
Lisa Bastarache, and
Xinnan Niu, and
Kenneth J Holroyd, and
Dan M Roden, and
Eric P Skaar, and
Colleen M Niswender, and
Lawrence J Marnett, and
Craig W Lindsley, and
Leeland B Ekstrom, and
Alan R Bentley, and
Gordon R Bernard, and
Charles C Hong, and
Joshua C Denny
January 2016,
Public health genomics,
Jill M Pulley, and
Jana K Shirey-Rice, and
Robert R Lavieri, and
Rebecca N Jerome, and
Nicole M Zaleski, and
David M Aronoff, and
Lisa Bastarache, and
Xinnan Niu, and
Kenneth J Holroyd, and
Dan M Roden, and
Eric P Skaar, and
Colleen M Niswender, and
Lawrence J Marnett, and
Craig W Lindsley, and
Leeland B Ekstrom, and
Alan R Bentley, and
Gordon R Bernard, and
Charles C Hong, and
Joshua C Denny
July 2021,
Cancers,
