Evaluation of a new latex agglutination method for detection of antibody to herpes simplex virus. 1988

P C DeGirolami, and J Dakos, and K Eichelberger, and S Biano
New England Deaconess Hospital, Boston, Massachusetts 02215.

A new latex agglutination (LA) test (Wampole Laboratories, Cranbury, N.J.) for detection of antibody to herpes simplex virus was compared with a reference complement fixation (CF) method in a premarket evaluation. Of 102 serum samples tested, 19 were LA negative and CF negative, 79 were LA positive and CF positive, and 4 were LA positive and CF negative. An enzyme immunoassay (M. A. Bioproducts, Walkersville, Md.) performed on the four LA-positive and CF-negative serum samples agreed with LA in all cases. Most LA titers were two to four doubling dilutions higher than CF titers. We conclude that this new LA test is a rapid, sensitive, and simple method for documentation of past infection with herpes simplex virus.

UI MeSH Term Description Entries
D007841 Latex Fixation Tests Passive agglutination tests in which antigen is adsorbed onto latex particles which then clump in the presence of antibody specific for the adsorbed antigen. (From Stedman, 26th ed) Latex Agglutination Tests,Agglutination Test, Latex,Agglutination Tests, Latex,Fixation Test, Latex,Fixation Tests, Latex,Latex Agglutination Test,Latex Fixation Test,Test, Latex Agglutination,Test, Latex Fixation,Tests, Latex Agglutination,Tests, Latex Fixation
D011933 Reagent Kits, Diagnostic Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use. Diagnostic Reagent Kits,Diagnostic Reagents and Test Kits,Diagnostic Test Kits,In Vitro Diagnostic Device,In Vitro Diagnostic Devices,In Vitro Diagnostic Medical Device,In Vitro Diagnostic Medical Devices,Kits, Diagnostic Reagent,Diagnostic Reagent Kit,Diagnostic Test Kit,Kit, Diagnostic Reagent,Kit, Diagnostic Test,Kits, Diagnostic Test,Reagent Kit, Diagnostic,Test Kit, Diagnostic,Test Kits, Diagnostic
D003168 Complement Fixation Tests Serologic tests based on inactivation of complement by the antigen-antibody complex (stage 1). Binding of free complement can be visualized by addition of a second antigen-antibody system such as red cells and appropriate red cell antibody (hemolysin) requiring complement for its completion (stage 2). Failure of the red cells to lyse indicates that a specific antigen-antibody reaction has taken place in stage 1. If red cells lyse, free complement is present indicating no antigen-antibody reaction occurred in stage 1. Complement Absorption Test, Conglutinating,Conglutination Reaction,Conglutinating Complement Absorption Test,Complement Fixation Test,Conglutination Reactions,Fixation Test, Complement,Fixation Tests, Complement,Reaction, Conglutination,Reactions, Conglutination,Test, Complement Fixation,Tests, Complement Fixation
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000914 Antibodies, Viral Immunoglobulins produced in response to VIRAL ANTIGENS. Viral Antibodies
D018139 Simplexvirus A genus of the family HERPESVIRIDAE, subfamily ALPHAHERPESVIRINAE, consisting of herpes simplex-like viruses. The type species is HERPESVIRUS 1, HUMAN. Herpes Simplex Virus,Herpesvirus 1, Saimiriine,Herpesvirus 1, Saimirine,Herpesvirus 16, Cercopithecine,Marmoset Virus,Cercopithecine Herpesvirus 16,Herpes Labialis Virus,Herpes-T Virus,Herpesvirus 1 (alpha), Saimirine,Herpesvirus Hominis,Herpesvirus Papio 2,Herpesvirus Platyrhinae,Marmoset Herpesvirus,Saimiriine Herpesvirus 1,Herpes Labialis Viruses,Herpes Simplex Viruses,Herpes T Virus,Herpes-T Viruses,Herpesvirus Homini,Herpesvirus, Marmoset,Herpesviruses, Marmoset,Homini, Herpesvirus,Hominis, Herpesvirus,Labialis Virus, Herpes,Labialis Viruses, Herpes,Marmoset Herpesviruses,Marmoset Viruses,Platyrhinae, Herpesvirus,Saimirine Herpesvirus 1,Simplexviruses,Virus, Herpes Labialis,Viruses, Herpes Labialis

Related Publications

P C DeGirolami, and J Dakos, and K Eichelberger, and S Biano
April 1988, Journal of clinical microbiology,
P C DeGirolami, and J Dakos, and K Eichelberger, and S Biano
March 1992, Enfermedades infecciosas y microbiologia clinica,
P C DeGirolami, and J Dakos, and K Eichelberger, and S Biano
September 1988, Diagnostic microbiology and infectious disease,
P C DeGirolami, and J Dakos, and K Eichelberger, and S Biano
May 1987, Journal of clinical microbiology,
P C DeGirolami, and J Dakos, and K Eichelberger, and S Biano
April 1990, Journal of clinical microbiology,
P C DeGirolami, and J Dakos, and K Eichelberger, and S Biano
July 1988, Journal of clinical microbiology,
P C DeGirolami, and J Dakos, and K Eichelberger, and S Biano
March 1989, European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology,
P C DeGirolami, and J Dakos, and K Eichelberger, and S Biano
January 1993, Diagnostic microbiology and infectious disease,
P C DeGirolami, and J Dakos, and K Eichelberger, and S Biano
January 1988, Diagnostic microbiology and infectious disease,
P C DeGirolami, and J Dakos, and K Eichelberger, and S Biano
September 1987, Diagnostic microbiology and infectious disease,
Copied contents to your clipboard!