-transparent.png){kind=logo}
An isolectin (BS I-B4) derived from Bandeiraea simplicifolia seeds and specific for terminal alpha-D-galactopyranosyl groups was found to be cytotoxic to Swiss 3T3 mouse cells. After mutagenesis and selection with BS I-B4, a variant clonal cell line resistant to both this isolectin and the alpha-D- and beta-D-galactose-binding lectin abrin was isolated. The parental cell line showed homogeneous and noninteracting binding sites for BS I-B4, whereas the variant cells exhibited a curved plot with a reduced number of binding regions. Another lectin, BS II, which is derived from the same seeds by specific for terminal N-acetyl-D-glucosaminyl groups, was cytotoxic to the variant but not the parental cells. These results suggest a possible lesion in the biosynthesis of cell surface structures resulting in the exposure of subterminal N-acetyl-D-glucosaminyl moieties in the variant line.
W S Stanley, and
B P Peters, and
D A Blake, and
D Yep, and
E H Chu, and
I J Goldstein
July 1977,
The Journal of biological chemistry,
W S Stanley, and
B P Peters, and
D A Blake, and
D Yep, and
E H Chu, and
I J Goldstein
November 1976,
Archives of biochemistry and biophysics,
W S Stanley, and
B P Peters, and
D A Blake, and
D Yep, and
E H Chu, and
I J Goldstein
October 1977,
Vox sanguinis,
W S Stanley, and
B P Peters, and
D A Blake, and
D Yep, and
E H Chu, and
I J Goldstein
January 1976,
Vox sanguinis,
W S Stanley, and
B P Peters, and
D A Blake, and
D Yep, and
E H Chu, and
I J Goldstein
October 1980,
Indian journal of biochemistry & biophysics,
W S Stanley, and
B P Peters, and
D A Blake, and
D Yep, and
E H Chu, and
I J Goldstein
January 1978,
Transfusion,
W S Stanley, and
B P Peters, and
D A Blake, and
D Yep, and
E H Chu, and
I J Goldstein
March 1974,
The Journal of biological chemistry,
W S Stanley, and
B P Peters, and
D A Blake, and
D Yep, and
E H Chu, and
I J Goldstein
July 1976,
Biochimica et biophysica acta,
W S Stanley, and
B P Peters, and
D A Blake, and
D Yep, and
E H Chu, and
I J Goldstein
November 1980,
European journal of biochemistry,
W S Stanley, and
B P Peters, and
D A Blake, and
D Yep, and
E H Chu, and
I J Goldstein
January 1976,
Biochemistry,
