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Cholecystokinin octapeptide-like (CCK-OP-like) immunoreactivity was localized in the rat brain by using the indirect immunofluorescence method. Specificity in immunohistochemical studies was demonstrated by the virtual elimination of staining with either preimmune sera or sera preadsorbed with CCK-OP and by the achievement of similar fluorescent patterns with two different primary anti-CCK-OP sera. CCK-OP-like fluorescence was localized in neuronal cell bodies, fibers, and varicose terminals. The most dense collections of CCK-OP cells occurred in the periaqueductal gray and in the dorsomedial hypothalamus. Substantial numbers of cells and fibers also were present in the medial/dorsal and perirhinal cortex; more limited groups of cells were found in the pyramidal layer of the hippocampus and in the dorsal raphe.
R B Innis, and
F M Corrêa, and
G R Uhl, and
B Schneider, and
S H Snyder
February 1984,
Brain research,
R B Innis, and
F M Corrêa, and
G R Uhl, and
B Schneider, and
S H Snyder
January 1981,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
R B Innis, and
F M Corrêa, and
G R Uhl, and
B Schneider, and
S H Snyder
January 1984,
Peptides,
R B Innis, and
F M Corrêa, and
G R Uhl, and
B Schneider, and
S H Snyder
December 1985,
Regulatory peptides,
R B Innis, and
F M Corrêa, and
G R Uhl, and
B Schneider, and
S H Snyder
January 1989,
Neuropeptides,
R B Innis, and
F M Corrêa, and
G R Uhl, and
B Schneider, and
S H Snyder
October 1987,
Life sciences,
R B Innis, and
F M Corrêa, and
G R Uhl, and
B Schneider, and
S H Snyder
June 1980,
Life sciences,
R B Innis, and
F M Corrêa, and
G R Uhl, and
B Schneider, and
S H Snyder
June 1983,
The American journal of physiology,
R B Innis, and
F M Corrêa, and
G R Uhl, and
B Schneider, and
S H Snyder
December 1978,
Proceedings of the National Academy of Sciences of the United States of America,
R B Innis, and
F M Corrêa, and
G R Uhl, and
B Schneider, and
S H Snyder
January 1981,
Peptides,
