Biomaterial Database

Cell-membrane hormone receptors: some perspectives on their structure and function relationship. 1988

C C Yip

Banting and Best Department of Medical Research, University of Toronto, Ont., Canada.

There are three structural regions common to hormone receptors on the cell membrane: an external region containing the ligand-specific binding domain, a hydrophobic region transversing the membrane, and a cytoplasmic region involved in the expression of activity. The structural features of these regions are broadly reviewed in regard to their functional roles. It is suggested that the specificity of cellular response to hormonal stimulation lies not only in the binding of a specific ligand by the external domain but also in the cytoplasmic region of a receptor. The cytoplasmic region can either interact specifically with a regulatory system or express its own specific ligand-dependent catalytic activity. The fundamental question of how ligand binding can lead to the expression and regulation of receptor activity is considered.

UI	MeSH Term	Description	Entries
D011956	Receptors, Cell Surface	Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.	Cell Surface Receptor,Cell Surface Receptors,Hormone Receptors, Cell Surface,Receptors, Endogenous Substances,Cell Surface Hormone Receptors,Endogenous Substances Receptors,Receptor, Cell Surface,Surface Receptor, Cell
D002462	Cell Membrane	The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.	Plasma Membrane,Cytoplasmic Membrane,Cell Membranes,Cytoplasmic Membranes,Membrane, Cell,Membrane, Cytoplasmic,Membrane, Plasma,Membranes, Cell,Membranes, Cytoplasmic,Membranes, Plasma,Plasma Membranes
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013329	Structure-Activity Relationship	The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.	Relationship, Structure-Activity,Relationships, Structure-Activity,Structure Activity Relationship,Structure-Activity Relationships