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The purpose of this study was to validate a method for determine the glomerular filtration rate (GFR) in healthy cynomolgus monkeys by using iohexol. Eighteen healthy cynomolgus macaque monkeys (age, 4 to 6 y [mean, 5 y]; weight, 2 to 6 kg [mean, 4 kg]) were randomly entered into 3 different doses groups (3 male and 3 female macaques per group) of 30, 60, 90 mg I/kg to receive an intravenous bolus injection of iohexol. Serum iohexol concentrations were determined by using liquid chromatography-tandem mass spectrometry, and clearance rate were determined by using WinNonlin software. The GFR value (mean ± SD) of each dose group was 2.50 ± 0.321, 2.65 ± 0.529, and 2.75 ± 0.385 mL/min/kg. These values did not differ significantly between dose levels or sexes. Iohexol clearance is a simple, precise method that is suitable for the determination of GFR in cynomolgus monkeys.
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