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Seven patients with glomerular proteinuria and hypertension (six with biopsy confirmation of glomerulonephritis, one with proteinuria after unilateral nephrectomy) were randomly given, for 14 days each, a calcium antagonist and then a conversion enzyme inhibitor, or vice versa, following a 14-day pause of all medication. Fractional albuminuria rose significantly during administration of calcium antagonists (P less than 0.05), while it decreased significantly during administration of converting enzyme inhibitor (P less than 0.05). The explanation for this finding may be that calcium antagonists raise glomerular capillary pressure by dilating the afferent arterioles, while converting enzyme inhibitors predominantly cause dilatation of the efferent arterioles.
O Mickisch, and
M Schmid, and
J F Mann, and
T Helder, and
F Bergen, and
E W Rauterberg, and
E Ritz
May 1992,
Kidney international. Supplement,
O Mickisch, and
M Schmid, and
J F Mann, and
T Helder, and
F Bergen, and
E W Rauterberg, and
E Ritz
June 1996,
Kidney international. Supplement,
O Mickisch, and
M Schmid, and
J F Mann, and
T Helder, and
F Bergen, and
E W Rauterberg, and
E Ritz
October 1990,
American journal of kidney diseases : the official journal of the National Kidney Foundation,
O Mickisch, and
M Schmid, and
J F Mann, and
T Helder, and
F Bergen, and
E W Rauterberg, and
E Ritz
November 1985,
The American journal of physiology,
O Mickisch, and
M Schmid, and
J F Mann, and
T Helder, and
F Bergen, and
E W Rauterberg, and
E Ritz
June 1994,
Archives of internal medicine,
O Mickisch, and
M Schmid, and
J F Mann, and
T Helder, and
F Bergen, and
E W Rauterberg, and
E Ritz
May 1991,
American journal of kidney diseases : the official journal of the National Kidney Foundation,
O Mickisch, and
M Schmid, and
J F Mann, and
T Helder, and
F Bergen, and
E W Rauterberg, and
E Ritz
August 1991,
Journal of the American Society of Nephrology : JASN,
O Mickisch, and
M Schmid, and
J F Mann, and
T Helder, and
F Bergen, and
E W Rauterberg, and
E Ritz
March 1997,
Renal failure,
O Mickisch, and
M Schmid, and
J F Mann, and
T Helder, and
F Bergen, and
E W Rauterberg, and
E Ritz
January 1991,
Nephron,
O Mickisch, and
M Schmid, and
J F Mann, and
T Helder, and
F Bergen, and
E W Rauterberg, and
E Ritz
August 1987,
Kidney international,
