-transparent.png){kind=logo}
Two analogs of rat atrial natriuretic factor, rANF7-28-NH2 and [Mpr7,Ala20,D-Arg27]rANF7-27-NH2, were prepared by the solid-phase method. These peptides had 2-fold and 7-fold less affinity, respectively, than rANF1-28 in binding to membranes prepared from cultured aortic smooth muscle cells, and both peptides were 5-fold less potent than rANF1-28 in relaxing serotonin-contracted rabbit aortic rings. rANF7-28-NH2 was rapidly degraded by rat kidney homogenates but [Mpr7,Ala20,D-Arg27]rANF7-27-NH2 had enhanced stability against rat kidney homogenate degradation. However, this in vitro stability did not translate into an extended duration of action in vivo.
Related Publications
J M Berman, and
T M Chen, and
R Sargent, and
S H Buck, and
P Shea, and
E F Heminger, and
R J Broersma
June 1998,
The journal of peptide research : official journal of the American Peptide Society,
J M Berman, and
T M Chen, and
R Sargent, and
S H Buck, and
P Shea, and
E F Heminger, and
R J Broersma
April 1994,
Journal of biochemical toxicology,
J M Berman, and
T M Chen, and
R Sargent, and
S H Buck, and
P Shea, and
E F Heminger, and
R J Broersma
May 1988,
The Journal of biological chemistry,
J M Berman, and
T M Chen, and
R Sargent, and
S H Buck, and
P Shea, and
E F Heminger, and
R J Broersma
August 1990,
International journal of peptide and protein research,
J M Berman, and
T M Chen, and
R Sargent, and
S H Buck, and
P Shea, and
E F Heminger, and
R J Broersma
May 1988,
Biochemical and biophysical research communications,
J M Berman, and
T M Chen, and
R Sargent, and
S H Buck, and
P Shea, and
E F Heminger, and
R J Broersma
July 1988,
International journal of peptide and protein research,
J M Berman, and
T M Chen, and
R Sargent, and
S H Buck, and
P Shea, and
E F Heminger, and
R J Broersma
October 1991,
Bioorganicheskaia khimiia,
J M Berman, and
T M Chen, and
R Sargent, and
S H Buck, and
P Shea, and
E F Heminger, and
R J Broersma
January 1988,
Doklady Akademii nauk SSSR,
J M Berman, and
T M Chen, and
R Sargent, and
S H Buck, and
P Shea, and
E F Heminger, and
R J Broersma
January 1989,
European journal of pharmacology,
J M Berman, and
T M Chen, and
R Sargent, and
S H Buck, and
P Shea, and
E F Heminger, and
R J Broersma
January 1999,
European journal of pharmacology,
