Bioresponsive Materials for Drug Delivery Based on Carboxymethyl Chitosan/Poly(γ-Glutamic Acid) Composite Microparticles. 2017

Xiaoting Yan, and Zongrui Tong, and Yu Chen, and Yanghe Mo, and Huaiyu Feng, and Peng Li, and Xiaosai Qu, and Shaohua Jin
School of Material Science and Engineering, Beijing Institute of Technology, Beijing 100081, China. yanxt911218@163.com.

Carboxymethyl chitosan (CMCS) microparticles are a potential candidate for hemostatic wound dressing. However, its low swelling property limits its hemostatic performance. Poly(γ-glutamic acid) (PGA) is a natural polymer with excellent hydrophilicity. In the current study, a novel CMCS/PGA composite microparticles with a dual-network structure was prepared by the emulsification/internal gelation method. The structure and thermal stability of the composite were determined by Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD), scanning electron microscope (SEM), X-ray photoelectron spectroscopy (XPS), and thermogravimetric analysis (TGA). The effects of preparation conditions on the swelling behavior of the composite were investigated. The results indicate that the swelling property of CMCS/PGA composite microparticles is pH sensitive. Levofloxacin (LFX) was immobilized in the composite microparticles as a model drug to evaluate the drug delivery performance of the composite. The release kinetics of LFX from the composite microparticles with different structures was determined. The results suggest that the CMCS/PGA composite microparticles are an excellent candidate carrier for drug delivery.

UI MeSH Term Description Entries
D007700 Kinetics The rate dynamics in chemical or physical systems.
D011099 Polyglutamic Acid A peptide that is a homopolymer of glutamic acid. Polyglutamate
D011108 Polymers Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS). Polymer
D004337 Drug Carriers Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers. Drug Carrier
D013818 Thermogravimetry Technique whereby the weight of a sample can be followed over a period of time while its temperature is being changed (usually increased at a constant rate). Thermogravimetries
D014961 X-Ray Diffraction The scattering of x-rays by matter, especially crystals, with accompanying variation in intensity due to interference effects. Analysis of the crystal structure of materials is performed by passing x-rays through them and registering the diffraction image of the rays (CRYSTALLOGRAPHY, X-RAY). (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Xray Diffraction,Diffraction, X-Ray,Diffraction, Xray,Diffractions, X-Ray,Diffractions, Xray,X Ray Diffraction,X-Ray Diffractions,Xray Diffractions
D016503 Drug Delivery Systems Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity. Drug Targeting,Delivery System, Drug,Delivery Systems, Drug,Drug Delivery System,Drug Targetings,System, Drug Delivery,Systems, Drug Delivery,Targeting, Drug,Targetings, Drug
D017550 Spectroscopy, Fourier Transform Infrared A spectroscopic technique in which a range of wavelengths is presented simultaneously with an interferometer and the spectrum is mathematically derived from the pattern thus obtained. FTIR,Fourier Transform Infrared Spectroscopy,Spectroscopy, Infrared, Fourier Transform
D048271 Chitosan Deacetylated CHITIN, a linear polysaccharide of deacetylated beta-1,4-D-glucosamine. It is used in HYDROGEL and to treat WOUNDS. Poliglusam
D056951 Photoelectron Spectroscopy The study of the energy of electrons ejected from matter by the photoelectric effect, i.e., as a direct result of absorption of energy from electromagnetic radiation. As the energies of the electrons are characteristic of a specific element, the measurement of the energy of these electrons is a technique used to determine the chemical composition of surfaces. Photoelectron Spectrometry,Electron Spectroscopy for Chemical Analysis,Photoelectron Emission Spectroscopy,Photoemission Spectroscopy,Ultra-Violet Photoelectron Spectroscopy,Ultraviolet Photoelectron Spectroscopy,X-Ray Photoelectron Spectroscopy,Xray Photoelectron Spectroscopy,Emission Spectroscopies, Photoelectron,Emission Spectroscopy, Photoelectron,Photoelectron Spectroscopy, Ultra-Violet,Photoelectron Spectroscopy, Ultraviolet,Photoelectron Spectroscopy, X-Ray,Photoelectron Spectroscopy, Xray,Spectrometry, Photoelectron,Spectroscopy, Photoelectron,Spectroscopy, Photoelectron Emission,Spectroscopy, Photoemission,Spectroscopy, Ultra-Violet Photoelectron,Spectroscopy, Ultraviolet Photoelectron,Spectroscopy, X-Ray Photoelectron,Spectroscopy, Xray Photoelectron,Ultra Violet Photoelectron Spectroscopy,X Ray Photoelectron Spectroscopy

Related Publications

Xiaoting Yan, and Zongrui Tong, and Yu Chen, and Yanghe Mo, and Huaiyu Feng, and Peng Li, and Xiaosai Qu, and Shaohua Jin
January 2012, Carbohydrate polymers,
Xiaoting Yan, and Zongrui Tong, and Yu Chen, and Yanghe Mo, and Huaiyu Feng, and Peng Li, and Xiaosai Qu, and Shaohua Jin
January 2012, Current drug delivery,
Xiaoting Yan, and Zongrui Tong, and Yu Chen, and Yanghe Mo, and Huaiyu Feng, and Peng Li, and Xiaosai Qu, and Shaohua Jin
April 2017, Marine drugs,
Xiaoting Yan, and Zongrui Tong, and Yu Chen, and Yanghe Mo, and Huaiyu Feng, and Peng Li, and Xiaosai Qu, and Shaohua Jin
August 2023, International journal of molecular sciences,
Xiaoting Yan, and Zongrui Tong, and Yu Chen, and Yanghe Mo, and Huaiyu Feng, and Peng Li, and Xiaosai Qu, and Shaohua Jin
May 2011, Drug delivery,
Xiaoting Yan, and Zongrui Tong, and Yu Chen, and Yanghe Mo, and Huaiyu Feng, and Peng Li, and Xiaosai Qu, and Shaohua Jin
August 2023, International journal of biological macromolecules,
Xiaoting Yan, and Zongrui Tong, and Yu Chen, and Yanghe Mo, and Huaiyu Feng, and Peng Li, and Xiaosai Qu, and Shaohua Jin
May 2012, International journal of pharmaceutics,
Xiaoting Yan, and Zongrui Tong, and Yu Chen, and Yanghe Mo, and Huaiyu Feng, and Peng Li, and Xiaosai Qu, and Shaohua Jin
January 2017, International journal of nanomedicine,
Xiaoting Yan, and Zongrui Tong, and Yu Chen, and Yanghe Mo, and Huaiyu Feng, and Peng Li, and Xiaosai Qu, and Shaohua Jin
October 2020, Carbohydrate polymers,
Xiaoting Yan, and Zongrui Tong, and Yu Chen, and Yanghe Mo, and Huaiyu Feng, and Peng Li, and Xiaosai Qu, and Shaohua Jin
October 2012, Biomaterials,
Copied contents to your clipboard!