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Effects of prostaglandins on the production of collagenase by rabbit uterine cervical fibroblasts were investigated. Exogenous prostaglandin E2 (PGE2) and PGF2 alpha significantly stimulated the production of collagenase in a dose dependent manner, whereas PGI2 did not. Addition of arachidonic acid in the presence of absence of indomethacin to the cell culture did not show any increase in collagenase production. Recombinant human interleukin-1 (rhIL-1) also promoted the production of cervical collagenase independently of endogenous prostaglandin(s). Furthermore both exogenous PGE2 and PGF2 alpha enhanced the rhIL-1-induced collagenase production whereas PGI2 and/or indomethacin did not. These results suggested that exogenous PGE2 and PGF2 alpha but not endogenous prostaglandin(s) participate in cervical ripening and dilation by enhancing collagenase production by rabbit uterine cervical cells.
H Goshowaki, and
A Ito, and
Y Mori
March 1981,
The Journal of laboratory and clinical medicine,
H Goshowaki, and
A Ito, and
Y Mori
March 1986,
Journal of pharmacobio-dynamics,
H Goshowaki, and
A Ito, and
Y Mori
September 1981,
Collagen and related research,
H Goshowaki, and
A Ito, and
Y Mori
January 1985,
Biomedica biochimica acta,
H Goshowaki, and
A Ito, and
Y Mori
May 2001,
Molecular human reproduction,
H Goshowaki, and
A Ito, and
Y Mori
January 1987,
The Biochemical journal,
H Goshowaki, and
A Ito, and
Y Mori
October 1986,
Biochimica et biophysica acta,
H Goshowaki, and
A Ito, and
Y Mori
March 1987,
Biology of reproduction,
H Goshowaki, and
A Ito, and
Y Mori
April 2001,
Journal of applied physiology (Bethesda, Md. : 1985),
H Goshowaki, and
A Ito, and
Y Mori
April 1984,
Biochemical medicine,
