BIOMAT Database Logo BIOMAT Database Logo

Radioactive iodine thyroid uptake in patients with amiodarone-iodine-induced thyroid dysfunction. 1988

E Martino, and L Bartalena, and S Mariotti, and F Aghini-Lombardi, and C Ceccarelli, and F Lippi, and M Piga, and A Loviselli, and L Braverman, and M Safran
Istituto di Medicina Interna, Cattedra di Endocrinologia, University of Cagliari, Italy.

Amiodarone, an iodine-rich drug, represents at the present, at least in Europe, one of the most common sources of iodine-induced thyroid dysfunction. The drug may induce both hypothyroidism and thyrotoxicosis. In spite of the large iodine intake occurring during amiodarone therapy, 131I thyroid uptake is detectable in patients with amiodarone-iodine-induced hypothyroidism, irrespective of the presence or absence of underlying thyroid disease. In contrast, in patients with amiodarone-iodine-induced thyrotoxicosis, 131I thyroid uptake is normal or even elevated in those with co-existent underlying thyroid disorders, whereas it is very low in those with an apparently normal thyroid gland. Perchlorate discharge test was performed in 8 patients with hypothyroidism and in 5 patients with hyperthyroidism induced by amiodarone: a positive test was found in all hypothyroid patients and a negative test in all hyperthyroid patients.

UI MeSH Term Description Entries
D006980 Hyperthyroidism Hypersecretion of THYROID HORMONES from the THYROID GLAND. Elevated levels of thyroid hormones increase BASAL METABOLIC RATE. Hyperthyroid,Primary Hyperthyroidism,Hyperthyroidism, Primary,Hyperthyroids
D007037 Hypothyroidism A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction. Central Hypothyroidism,Primary Hypothyroidism,Secondary Hypothyroidism,TSH Deficiency,Thyroid-Stimulating Hormone Deficiency,Central Hypothyroidisms,Deficiency, TSH,Deficiency, Thyroid-Stimulating Hormone,Hormone Deficiency, Thyroid-Stimulating,Hypothyroidism, Central,Hypothyroidism, Primary,Hypothyroidism, Secondary,Hypothyroidisms,Primary Hypothyroidisms,Secondary Hypothyroidisms,TSH Deficiencies,Thyroid Stimulating Hormone Deficiency,Thyroid-Stimulating Hormone Deficiencies
D007457 Iodine Radioisotopes Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes. Radioisotopes, Iodine
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010472 Perchlorates Compounds that contain the Cl( Perchloric Acid Derivatives,Perchloric Acids,Acids, Perchloric
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly

Related Publications

E Martino, and L Bartalena, and S Mariotti, and F Aghini-Lombardi, and C Ceccarelli, and F Lippi, and M Piga, and A Loviselli, and L Braverman, and M Safran
Radioactive iodine uptake studies in patients with thyroid dysfunction.
July 1960, New York state journal of medicine,
E Martino, and L Bartalena, and S Mariotti, and F Aghini-Lombardi, and C Ceccarelli, and F Lippi, and M Piga, and A Loviselli, and L Braverman, and M Safran
Amiodarone-induced thyroid dysfunction in cardiac patients from areas with iodine deficiency.
January 2004, Romanian journal of internal medicine = Revue roumaine de medecine interne,
E Martino, and L Bartalena, and S Mariotti, and F Aghini-Lombardi, and C Ceccarelli, and F Lippi, and M Piga, and A Loviselli, and L Braverman, and M Safran
Treating amiodarone-induced thyrotoxicosis with radioactive iodine.
September 2004, Tennessee medicine : journal of the Tennessee Medical Association,
E Martino, and L Bartalena, and S Mariotti, and F Aghini-Lombardi, and C Ceccarelli, and F Lippi, and M Piga, and A Loviselli, and L Braverman, and M Safran
[Thyroid uptake of I131 in iodine-induced thyroid pathology caused by amiodarone].
April 1988, Recenti progressi in medicina,
E Martino, and L Bartalena, and S Mariotti, and F Aghini-Lombardi, and C Ceccarelli, and F Lippi, and M Piga, and A Loviselli, and L Braverman, and M Safran
Twenty-four hour radioactive iodine uptake in 35 patients with amiodarone associated thyrotoxicosis.
December 1985, Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
E Martino, and L Bartalena, and S Mariotti, and F Aghini-Lombardi, and C Ceccarelli, and F Lippi, and M Piga, and A Loviselli, and L Braverman, and M Safran
Thyroid uptake of radioactive iodine in hyperthyroidism.
August 1977, JAMA,
E Martino, and L Bartalena, and S Mariotti, and F Aghini-Lombardi, and C Ceccarelli, and F Lippi, and M Piga, and A Loviselli, and L Braverman, and M Safran
Amiodarone-induced thyroid dysfunction.
June 2006, Critical care nurse,
E Martino, and L Bartalena, and S Mariotti, and F Aghini-Lombardi, and C Ceccarelli, and F Lippi, and M Piga, and A Loviselli, and L Braverman, and M Safran
Amiodarone-induced thyroid dysfunction.
March 2005, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
E Martino, and L Bartalena, and S Mariotti, and F Aghini-Lombardi, and C Ceccarelli, and F Lippi, and M Piga, and A Loviselli, and L Braverman, and M Safran
Amiodarone-induced thyroid dysfunction.
May 2015, Journal of intensive care medicine,
E Martino, and L Bartalena, and S Mariotti, and F Aghini-Lombardi, and C Ceccarelli, and F Lippi, and M Piga, and A Loviselli, and L Braverman, and M Safran
Amiodarone-induced thyroid dysfunction.
October 1993, Clinical pharmacy,
Copied contents to your clipboard!