Biomaterial Database

Effect of topical fluoride treatments on fluoride distribution during in vitro caries-like lesion formation. 1988

B H Clarkson, and S E Hansen, and J S Wefel

School of Dental Medicine, Department of Pediatric Dentistry, University of Connecticut, Farmington.

Tooth sections were treated in vitro for 4 min with APF, SnF2, or received no treatment. Each treatment group then received washes of KOH, (24 h), an inorganic solution (24 h), or DDH2O (2 min) and were placed into dialyzed 15% w/v gel (pH 4.3) containing 0.15 mM hydroxyapatite, but no fluoride (less than 0.02 ppm F). Adjacent nontreated sound enamel acted as the control. Lesion microdissection, after 2 weeks exposure to the acidified gel, revealed an inverse relationship between lesion body fluoride concentration and lesion depth. The lesion depth was smallest, and the lesion body fluoride concentration was greatest in both fluoride-treated groups after a 2-min DDH2O wash, a 24-hour inorganic wash, and a 24-hour KOH wash, respectively. These data support the theory that the progress of carious lesions is related to the fluoride concentration in the lesion and that the fluoride concentration in the lesion is related to the acquired fluoride concentration in sound enamel.

UI	MeSH Term	Description	Entries
D010710	Phosphates	Inorganic salts of phosphoric acid.	Inorganic Phosphate,Phosphates, Inorganic,Inorganic Phosphates,Orthophosphate,Phosphate,Phosphate, Inorganic
D011188	Potassium	An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
D002122	Calcium Chloride	A salt used to replenish calcium levels, as an acid-producing diuretic, and as an antidote for magnesium poisoning.	Calcium Chloride Dihydrate,Calcium Chloride, Anhydrous
D003731	Dental Caries	Localized destruction of the tooth surface initiated by decalcification of the enamel followed by enzymatic lysis of organic structures and leading to cavity formation. If left unchecked, the cavity may penetrate the enamel and dentin and reach the pulp.	Caries, Dental,Carious Lesions,Dental Cavities,Dental Cavity,Dental Decay,Dental White Spots,Carious Dentin,Decay, Dental,Dental White Spot,White Spot, Dental,White Spots, Dental,Carious Dentins,Carious Lesion,Cavities, Dental,Cavity, Dental,Dentin, Carious,Dentins, Carious,Lesion, Carious,Lesions, Carious,Spot, Dental White,Spots, Dental White
D003743	Dental Enamel	A hard thin translucent layer of calcified substance which envelops and protects the dentin of the crown of the tooth. It is the hardest substance in the body and is almost entirely composed of calcium salts. Under the microscope, it is composed of thin rods (enamel prisms) held together by cementing substance, and surrounded by an enamel sheath. (From Jablonski, Dictionary of Dentistry, 1992, p286)	Enamel,Enamel Cuticle,Dental Enamels,Enamel, Dental,Enamels, Dental,Cuticle, Enamel,Cuticles, Enamel,Enamel Cuticles,Enamels
D005459	Fluorides	Inorganic salts of hydrofluoric acid, HF, in which the fluorine atom is in the -1 oxidation state. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Sodium and stannous salts are commonly used in dentifrices.	Fluoride
D005460	Fluorides, Topical	Fluorides, usually in pastes or gels, used for topical application to reduce the incidence of DENTAL CARIES.	Fluoride Varnishes,Topical Fluorides,Varnishes, Fluoride
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006878	Hydroxides	Inorganic compounds that contain the OH- group.
D000149	Acidulated Phosphate Fluoride	A sodium fluoride solution, paste or powder, which has been acidulated to pH 3 to 4 and buffered with a phosphate. It is used in the prevention of dental caries.	Phosphate Fluoride, Acidulated,Acid Phosphate Fluoride,Fluoride, Acid Phosphate,Fluoride, Acidulated Phosphate