-transparent.png){kind=logo}
Long-term dietary administration of the adrenal hormone dehydroepiandrosterone (DHEA) to male Sprague-Dawley rats induced significant alterations in the activities of enzymes involved in liver carbohydrate metabolism. Although glycogen synthase activity was increased and phosphorylase decreased, glycogen stores were reduced. This was presumably related to lysosomal glycogen degradation, since alpha-glucosidase was increased. All rate-limiting enzymes of glucose metabolism which were studied (glucose-6-phosphate dehydrogenase, total hexokinases, pyruvate kinase, fructose-1,6-bisphosphatase) revealed markedly reduced activity, only glucose-6-phosphatase activity was increased. These enzymatic changes point to a far-reaching metabolic shift towards energy loss via decreased glucose consumption and increased glucose output. The enzyme pattern induced by DHEA is in many respects opposite to that induced in preneoplastic and neoplastic liver lesions by chemical hepatocarcinogens.
D Mayer, and
E Weber, and
M A Moore, and
I Letsch, and
E Filsinger, and
P Bannasch
December 1992,
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes,
D Mayer, and
E Weber, and
M A Moore, and
I Letsch, and
E Filsinger, and
P Bannasch
January 1976,
Annals of the New York Academy of Sciences,
D Mayer, and
E Weber, and
M A Moore, and
I Letsch, and
E Filsinger, and
P Bannasch
January 1992,
Pathobiology : journal of immunopathology, molecular and cellular biology,
D Mayer, and
E Weber, and
M A Moore, and
I Letsch, and
E Filsinger, and
P Bannasch
August 1996,
The Journal of steroid biochemistry and molecular biology,
D Mayer, and
E Weber, and
M A Moore, and
I Letsch, and
E Filsinger, and
P Bannasch
October 1963,
Archives of biochemistry and biophysics,
D Mayer, and
E Weber, and
M A Moore, and
I Letsch, and
E Filsinger, and
P Bannasch
December 1958,
The Journal of biological chemistry,
D Mayer, and
E Weber, and
M A Moore, and
I Letsch, and
E Filsinger, and
P Bannasch
November 1967,
The Biochemical journal,
D Mayer, and
E Weber, and
M A Moore, and
I Letsch, and
E Filsinger, and
P Bannasch
January 1989,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
D Mayer, and
E Weber, and
M A Moore, and
I Letsch, and
E Filsinger, and
P Bannasch
March 1966,
Naika hokan. Japanese archives of internal medicine,
D Mayer, and
E Weber, and
M A Moore, and
I Letsch, and
E Filsinger, and
P Bannasch
November 2015,
Diabetes research and clinical practice,
