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Human recombinant tumor necrosis factor-alpha (TNF) was found to stimulate the production of prostaglandins (PG) by cultured rat mesangial cells. This effect was demonstrable from 6 h, was dose dependent and affected the synthesis of PGE2, PGF2 alpha, and 6-keto-PGF1 alpha. It required both RNA and protein synthesis but was not associated with a modification of cell proliferation. TNF also stimulated adenosine 3'-5' cyclic monophosphate (cAMP) levels in the mesangial cell culture medium. Indomethacin suppressed the effect of TNF on PGs but only reduced that on cAMP, indicating that PG production partly mediates the increase in cAMP. These findings demonstrate that mesangial cells can be a target for TNF and that the mechanism of TNF action includes stimulation of both PG production and cAMP levels.
L Baud, and
J Perez, and
G Friedlander, and
R Ardaillou
February 1991,
American journal of hypertension,
L Baud, and
J Perez, and
G Friedlander, and
R Ardaillou
April 1997,
Kidney international,
L Baud, and
J Perez, and
G Friedlander, and
R Ardaillou
July 1999,
FEMS microbiology letters,
L Baud, and
J Perez, and
G Friedlander, and
R Ardaillou
January 1990,
Eicosanoids,
L Baud, and
J Perez, and
G Friedlander, and
R Ardaillou
August 1993,
The Journal of laboratory and clinical medicine,
L Baud, and
J Perez, and
G Friedlander, and
R Ardaillou
May 1992,
The Journal of laboratory and clinical medicine,
L Baud, and
J Perez, and
G Friedlander, and
R Ardaillou
November 1992,
Journal of cellular physiology,
L Baud, and
J Perez, and
G Friedlander, and
R Ardaillou
April 1986,
Biochemical and biophysical research communications,
L Baud, and
J Perez, and
G Friedlander, and
R Ardaillou
May 1989,
Kidney international,
L Baud, and
J Perez, and
G Friedlander, and
R Ardaillou
February 1997,
The Journal of biological chemistry,
