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Immunoreactive alpha-melanocyte stimulating hormone (IR-alpha-MSH)-like activity was measured by radioimmunoassay (RIA) in at term pregnancy amniotic fluid prior and after adsorption on a Sep-pak C18 cartridge. alpha-MSH activity was 3-4 times lower after Sep-pak purification but, unlike the levels of IR-alpha-MSH in the fluid analyzed in toto, increased linearly with the volume of fluid analyzed. Furthermore, fractionation by high pressure liquid chromatography (HPLC) revealed that IR-alpha-MSH recovered from the Sep-pak was due to several peptides rather than to a single peptide. The most abundant of them (50% of total activity) behaved like authentic des-acetyl-alpha-MSH. Since des-acetyl-alpha-MSH is also the most abundant alpha-MSH-like peptide in the fetal pituitary gland, the present results suggest that the fetal pituitary is a main source of des-acetyl-alpha-MSH in the amniotic fluid.
A Mauri, and
A Argiolas, and
M R Melis, and
L Lai, and
W Fratta, and
A Caruso, and
A Lanzone, and
F Serri, and
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S Mancuso
January 1982,
Peptides,
A Mauri, and
A Argiolas, and
M R Melis, and
L Lai, and
W Fratta, and
A Caruso, and
A Lanzone, and
F Serri, and
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January 1985,
Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie,
A Mauri, and
A Argiolas, and
M R Melis, and
L Lai, and
W Fratta, and
A Caruso, and
A Lanzone, and
F Serri, and
F Caminiti, and
S Mancuso
April 1986,
Endocrinology,
A Mauri, and
A Argiolas, and
M R Melis, and
L Lai, and
W Fratta, and
A Caruso, and
A Lanzone, and
F Serri, and
F Caminiti, and
S Mancuso
February 1981,
The Journal of clinical endocrinology and metabolism,
A Mauri, and
A Argiolas, and
M R Melis, and
L Lai, and
W Fratta, and
A Caruso, and
A Lanzone, and
F Serri, and
F Caminiti, and
S Mancuso
April 1979,
Immunology,
A Mauri, and
A Argiolas, and
M R Melis, and
L Lai, and
W Fratta, and
A Caruso, and
A Lanzone, and
F Serri, and
F Caminiti, and
S Mancuso
November 1999,
Prenatal diagnosis,
A Mauri, and
A Argiolas, and
M R Melis, and
L Lai, and
W Fratta, and
A Caruso, and
A Lanzone, and
F Serri, and
F Caminiti, and
S Mancuso
January 1976,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
A Mauri, and
A Argiolas, and
M R Melis, and
L Lai, and
W Fratta, and
A Caruso, and
A Lanzone, and
F Serri, and
F Caminiti, and
S Mancuso
January 1989,
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience,
A Mauri, and
A Argiolas, and
M R Melis, and
L Lai, and
W Fratta, and
A Caruso, and
A Lanzone, and
F Serri, and
F Caminiti, and
S Mancuso
January 1979,
Brain research bulletin,
A Mauri, and
A Argiolas, and
M R Melis, and
L Lai, and
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A Caruso, and
A Lanzone, and
F Serri, and
F Caminiti, and
S Mancuso
October 1987,
Brain research,
