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In order to investigate the bleeding tendency in clinically identified carriers of hemophilia, a self-administered questionnaire was held among 135 carriers of hemophilia A and B, 25 females with relatives with hemophilia and a matched group consisting of 60 females without relatives with hemophilia. Carriers of hemophilia appeared to suffer more often from bleeding than their relatives or the matched unrelated control group. A relation was seen between factor VIII:C or IX:C activity and the tendency to bleed. Obligatory carriers with normal factor VIII:C levels showed no bleeding tendency and were in this respect similar to a group of 25 females with relatives with hemophilia. This study shows that it is important to assay factor VIII:C or IX:C also in those women in whom the carrier status has already been established otherwise.
E P Mauser Bunschoten, and
J C van Houwelingen, and
E J Sjamsoedin Visser, and
P J van Dijken, and
A J Kok, and
J J Sixma
January 2022,
BioMed research international,
E P Mauser Bunschoten, and
J C van Houwelingen, and
E J Sjamsoedin Visser, and
P J van Dijken, and
A J Kok, and
J J Sixma
May 2014,
Journal of pediatric hematology/oncology,
E P Mauser Bunschoten, and
J C van Houwelingen, and
E J Sjamsoedin Visser, and
P J van Dijken, and
A J Kok, and
J J Sixma
January 1966,
Bibliotheca haematologica,
E P Mauser Bunschoten, and
J C van Houwelingen, and
E J Sjamsoedin Visser, and
P J van Dijken, and
A J Kok, and
J J Sixma
May 2009,
Journal of thrombosis and haemostasis : JTH,
E P Mauser Bunschoten, and
J C van Houwelingen, and
E J Sjamsoedin Visser, and
P J van Dijken, and
A J Kok, and
J J Sixma
November 2008,
Journal of thrombosis and haemostasis : JTH,
E P Mauser Bunschoten, and
J C van Houwelingen, and
E J Sjamsoedin Visser, and
P J van Dijken, and
A J Kok, and
J J Sixma
April 2021,
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis,
E P Mauser Bunschoten, and
J C van Houwelingen, and
E J Sjamsoedin Visser, and
P J van Dijken, and
A J Kok, and
J J Sixma
December 2017,
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis,
E P Mauser Bunschoten, and
J C van Houwelingen, and
E J Sjamsoedin Visser, and
P J van Dijken, and
A J Kok, and
J J Sixma
December 1992,
Casopis lekaru ceskych,
E P Mauser Bunschoten, and
J C van Houwelingen, and
E J Sjamsoedin Visser, and
P J van Dijken, and
A J Kok, and
J J Sixma
April 2024,
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis,
E P Mauser Bunschoten, and
J C van Houwelingen, and
E J Sjamsoedin Visser, and
P J van Dijken, and
A J Kok, and
J J Sixma
January 2005,
Gaceta medica de Mexico,
