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Binding activities and metabolic effects of atrial natriuretic peptide (ANP) were examined in rat brown fat. ANP binding sites were identified in thin sections of brown adipose. Binding of [125I]-ANP to brown fat membranes was specific, saturable and time-dependent. A single class of high affinity sites (Kd, 1.7 nM; Bmax, 226 fmol/mg protein) was present. ANP increased cGMP synthesis in isolated cells (EC50, 2.5 x 10(-9) M), but did not alter epinephrine-stimulated glycerol production. The results demonstrate the presence of specific ANP receptors in brown fat, activation of which increases cGMP formation; however, since neither ANP nor cGMP affect lipolysis, the biological importance of these receptors remains unknown.
H Okamura, and
P A Kelly, and
J G Chabot, and
G Morel, and
M Belles-Isles, and
S Heisler
January 2023,
Obesity reviews : an official journal of the International Association for the Study of Obesity,
H Okamura, and
P A Kelly, and
J G Chabot, and
G Morel, and
M Belles-Isles, and
S Heisler
January 1988,
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H Okamura, and
P A Kelly, and
J G Chabot, and
G Morel, and
M Belles-Isles, and
S Heisler
November 1994,
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H Okamura, and
P A Kelly, and
J G Chabot, and
G Morel, and
M Belles-Isles, and
S Heisler
January 2017,
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H Okamura, and
P A Kelly, and
J G Chabot, and
G Morel, and
M Belles-Isles, and
S Heisler
November 1988,
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,
H Okamura, and
P A Kelly, and
J G Chabot, and
G Morel, and
M Belles-Isles, and
S Heisler
December 2015,
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H Okamura, and
P A Kelly, and
J G Chabot, and
G Morel, and
M Belles-Isles, and
S Heisler
December 1997,
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H Okamura, and
P A Kelly, and
J G Chabot, and
G Morel, and
M Belles-Isles, and
S Heisler
December 1988,
American journal of obstetrics and gynecology,
H Okamura, and
P A Kelly, and
J G Chabot, and
G Morel, and
M Belles-Isles, and
S Heisler
September 2007,
Obesity (Silver Spring, Md.),
H Okamura, and
P A Kelly, and
J G Chabot, and
G Morel, and
M Belles-Isles, and
S Heisler
June 1990,
American journal of hypertension,
