-transparent.png){kind=logo}
Potent and selective activity of a new carbocyclic nucleoside analog (carbovir: NSC 614846) against human immunodeficiency virus in vitro. 1988
R Vince, and
M Hua, and
J Brownell, and
S Daluge, and
F C Lee, and
W M Shannon, and
G C Lavelle, and
J Qualls, and
O S Weislow, and
R Kiser
Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis 55455.
Carbocyclic 2',3'-didehydro-2',3'-dideoxyguanosine (Carbovir: NSC 614846), a novel nucleoside analog, emerged as a potent and selective anti-HIV agent from a large screening program conducted by the National Cancer Institute and its contractors. Its hydrolytic stability and its ability to inhibit the infectivity and replication of HIV in T-cells at concentrations of approximately 200- to 400-fold below toxic concentrations make carbovir a top-priority candidate for development as a potential antiretroviral agent in the treatment of AIDS patients.
Related Publications
R Vince, and
M Hua, and
J Brownell, and
S Daluge, and
F C Lee, and
W M Shannon, and
G C Lavelle, and
J Qualls, and
O S Weislow, and
R Kiser
May 1997,
Antimicrobial agents and chemotherapy,
R Vince, and
M Hua, and
J Brownell, and
S Daluge, and
F C Lee, and
W M Shannon, and
G C Lavelle, and
J Qualls, and
O S Weislow, and
R Kiser
February 1991,
Antiviral research,
R Vince, and
M Hua, and
J Brownell, and
S Daluge, and
F C Lee, and
W M Shannon, and
G C Lavelle, and
J Qualls, and
O S Weislow, and
R Kiser
October 1990,
Biochemistry,
R Vince, and
M Hua, and
J Brownell, and
S Daluge, and
F C Lee, and
W M Shannon, and
G C Lavelle, and
J Qualls, and
O S Weislow, and
R Kiser
June 1990,
Antimicrobial agents and chemotherapy,
R Vince, and
M Hua, and
J Brownell, and
S Daluge, and
F C Lee, and
W M Shannon, and
G C Lavelle, and
J Qualls, and
O S Weislow, and
R Kiser
January 1991,
Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie,
R Vince, and
M Hua, and
J Brownell, and
S Daluge, and
F C Lee, and
W M Shannon, and
G C Lavelle, and
J Qualls, and
O S Weislow, and
R Kiser
January 1990,
Drug metabolism and disposition: the biological fate of chemicals,
R Vince, and
M Hua, and
J Brownell, and
S Daluge, and
F C Lee, and
W M Shannon, and
G C Lavelle, and
J Qualls, and
O S Weislow, and
R Kiser
September 1998,
Antimicrobial agents and chemotherapy,
R Vince, and
M Hua, and
J Brownell, and
S Daluge, and
F C Lee, and
W M Shannon, and
G C Lavelle, and
J Qualls, and
O S Weislow, and
R Kiser
January 1992,
The Journal of biological chemistry,
R Vince, and
M Hua, and
J Brownell, and
S Daluge, and
F C Lee, and
W M Shannon, and
G C Lavelle, and
J Qualls, and
O S Weislow, and
R Kiser
June 2020,
Viruses,
R Vince, and
M Hua, and
J Brownell, and
S Daluge, and
F C Lee, and
W M Shannon, and
G C Lavelle, and
J Qualls, and
O S Weislow, and
R Kiser
September 1987,
Biochemical pharmacology,
