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Phase II study of tiazofurin (NSC 286193) in the treatment of advanced small cell bronchogenic carcinoma. 1988
P Y Holoye, and
D T Carr, and
H M Dhingra, and
B S Glisson, and
J S Lee, and
W K Murphy, and
T Umsawasdi, and
D Jeffries
Department of Medical Oncology, University of Texas M.D. Anderson Hospital and Tumor Institute, Houston 77030.
Fourteen evaluable patients with small cell bronchogenic carcinoma received tiazofurin, an inhibitor of inosine monophosphate dehydrogenase, that progressed after one combination chemotherapy. No objective remission was observed at the dosage of 800 mg/m2 for 5 consecutive days. Toxicity was moderate.
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