BIOMAT Database Logo BIOMAT Database Logo

Synergic bactericidal effects of reduced graphene oxide and silver nanoparticles against Gram-positive and Gram-negative bacteria. 2017

Karthika Prasad, and G S Lekshmi, and Kola Ostrikov, and Vanessa Lussini, and James Blinco, and Mandhakini Mohandas, and Krasimir Vasilev, and Steven Bottle, and Kateryna Bazaka, and Kostya Ostrikov
School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, Queensland, 4000, Australia.

Reduced graphene oxide (rGO) is a promising antibacterial material, the efficacy of which can be further enhanced by the addition of silver nanoparticles (nAg). In this study, the mechanisms of antibacterial activity of rGO-nAg nanocomposite against several important human pathogenic multi-drug resistant bacteria, namely Gram-positive coccal Staphylococcus aureus and Gram-negative rod-shaped Escherichia coli and Proteus mirabilis are investigated. At the same concentration (100 µg/ml), rGO-nAg nanocomposite was significantly more effective against all three pathogens than either rGO or nAg. The nanocomposite was equally active against P. mirabilis and S. aureus as systemic antibiotic nitrofurantoin, and significantly more effective against E. coli. Importantly, the inhibition was much faster in the case of rGO-nAg nanocomposite compared to nitrofurantoin, attributed to the synergistic effects of rGO-nAg mediated contact killing and oxidative stress. This study may provide new insights for the better understanding of antibacterial actions of rGO-nAg nanocomposite and for the better designing of graphene-based antibiotics or other biomedical applications.

UI MeSH Term Description Entries
D010087 Oxides Binary compounds of oxygen containing the anion O(2-). The anion combines with metals to form alkaline oxides and non-metals to form acidic oxides. Oxide
D004357 Drug Synergism The action of a drug in promoting or enhancing the effectiveness of another drug. Drug Potentiation,Drug Augmentation,Augmentation, Drug,Augmentations, Drug,Drug Augmentations,Drug Potentiations,Drug Synergisms,Potentiation, Drug,Potentiations, Drug,Synergism, Drug,Synergisms, Drug
D006090 Gram-Negative Bacteria Bacteria which lose crystal violet stain but are stained pink when treated by Gram's method. Gram Negative Bacteria
D006094 Gram-Positive Bacteria Bacteria which retain the crystal violet stain when treated by Gram's method. Gram Positive Bacteria
D006108 Graphite An allotropic form of carbon that is used in pencils, as a lubricant, and in matches and explosives. It is obtained by mining and its dust can cause lung irritation. Graphene
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000900 Anti-Bacterial Agents Substances that inhibit the growth or reproduction of BACTERIA. Anti-Bacterial Agent,Anti-Bacterial Compound,Anti-Mycobacterial Agent,Antibacterial Agent,Antibiotics,Antimycobacterial Agent,Bacteriocidal Agent,Bacteriocide,Anti-Bacterial Compounds,Anti-Mycobacterial Agents,Antibacterial Agents,Antibiotic,Antimycobacterial Agents,Bacteriocidal Agents,Bacteriocides,Agent, Anti-Bacterial,Agent, Anti-Mycobacterial,Agent, Antibacterial,Agent, Antimycobacterial,Agent, Bacteriocidal,Agents, Anti-Bacterial,Agents, Anti-Mycobacterial,Agents, Antibacterial,Agents, Antimycobacterial,Agents, Bacteriocidal,Anti Bacterial Agent,Anti Bacterial Agents,Anti Bacterial Compound,Anti Bacterial Compounds,Anti Mycobacterial Agent,Anti Mycobacterial Agents,Compound, Anti-Bacterial,Compounds, Anti-Bacterial
D012834 Silver An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.
D017550 Spectroscopy, Fourier Transform Infrared A spectroscopic technique in which a range of wavelengths is presented simultaneously with an interferometer and the spectrum is mathematically derived from the pattern thus obtained. FTIR,Fourier Transform Infrared Spectroscopy,Spectroscopy, Infrared, Fourier Transform
D050296 Microbial Viability Ability of a microbe to survive under given conditions. This can also be related to a colony's ability to replicate. Bacterial Viability,Virus Viability,Bacteria Viability,Microbial Inactivation,Inactivation, Microbial,Viability, Bacteria,Viability, Bacterial,Viability, Microbial,Viability, Virus

Related Publications

Karthika Prasad, and G S Lekshmi, and Kola Ostrikov, and Vanessa Lussini, and James Blinco, and Mandhakini Mohandas, and Krasimir Vasilev, and Steven Bottle, and Kateryna Bazaka, and Kostya Ostrikov
Synthesis and antibacterial activity of silver nanoparticles against gram-positive and gram-negative bacteria.
January 2012, Nanomedicine : nanotechnology, biology, and medicine,
Karthika Prasad, and G S Lekshmi, and Kola Ostrikov, and Vanessa Lussini, and James Blinco, and Mandhakini Mohandas, and Krasimir Vasilev, and Steven Bottle, and Kateryna Bazaka, and Kostya Ostrikov
Antibacterial activity of glutathione-coated silver nanoparticles against Gram positive and Gram negative bacteria.
May 2012, Langmuir : the ACS journal of surfaces and colloids,
Karthika Prasad, and G S Lekshmi, and Kola Ostrikov, and Vanessa Lussini, and James Blinco, and Mandhakini Mohandas, and Krasimir Vasilev, and Steven Bottle, and Kateryna Bazaka, and Kostya Ostrikov
Antibacterial activity of silver-doped hydroxyapatite nanoparticles against gram-positive and gram-negative bacteria.
June 2012, Nanoscale research letters,
Karthika Prasad, and G S Lekshmi, and Kola Ostrikov, and Vanessa Lussini, and James Blinco, and Mandhakini Mohandas, and Krasimir Vasilev, and Steven Bottle, and Kateryna Bazaka, and Kostya Ostrikov
Evaluation of the toxicities of silver and silver sulfide nanoparticles against Gram-positive and Gram-negative bacteria.
May 2019, IET nanobiotechnology,
Karthika Prasad, and G S Lekshmi, and Kola Ostrikov, and Vanessa Lussini, and James Blinco, and Mandhakini Mohandas, and Krasimir Vasilev, and Steven Bottle, and Kateryna Bazaka, and Kostya Ostrikov
Mechanistic antimicrobial approach of extracellularly synthesized silver nanoparticles against gram positive and gram negative bacteria.
September 2013, Journal of hazardous materials,
Karthika Prasad, and G S Lekshmi, and Kola Ostrikov, and Vanessa Lussini, and James Blinco, and Mandhakini Mohandas, and Krasimir Vasilev, and Steven Bottle, and Kateryna Bazaka, and Kostya Ostrikov
Enhanced antibacterial and anti-biofilm activities of silver nanoparticles against Gram-negative and Gram-positive bacteria.
January 2014, Nanoscale research letters,
Karthika Prasad, and G S Lekshmi, and Kola Ostrikov, and Vanessa Lussini, and James Blinco, and Mandhakini Mohandas, and Krasimir Vasilev, and Steven Bottle, and Kateryna Bazaka, and Kostya Ostrikov
Ceftriaxone against gram-negative and gram-positive bacteria: bactericidal and post-antibiotic effect.
June 1985, Chemioterapia : international journal of the Mediterranean Society of Chemotherapy,
Karthika Prasad, and G S Lekshmi, and Kola Ostrikov, and Vanessa Lussini, and James Blinco, and Mandhakini Mohandas, and Krasimir Vasilev, and Steven Bottle, and Kateryna Bazaka, and Kostya Ostrikov
Antibacterial Activity of Colloidal Silver against Gram-Negative and Gram-Positive Bacteria.
January 2020, Antibiotics (Basel, Switzerland),
Karthika Prasad, and G S Lekshmi, and Kola Ostrikov, and Vanessa Lussini, and James Blinco, and Mandhakini Mohandas, and Krasimir Vasilev, and Steven Bottle, and Kateryna Bazaka, and Kostya Ostrikov
Synthesis, characterization and antibacterial activity against Gram positive and Gram negative bacteria of biomimetically coated silver nanoparticles.
August 2011, Langmuir : the ACS journal of surfaces and colloids,
Karthika Prasad, and G S Lekshmi, and Kola Ostrikov, and Vanessa Lussini, and James Blinco, and Mandhakini Mohandas, and Krasimir Vasilev, and Steven Bottle, and Kateryna Bazaka, and Kostya Ostrikov
Antimicrobial activity of metal oxide nanoparticles against Gram-positive and Gram-negative bacteria: a comparative study.
January 2012, International journal of nanomedicine,
Copied contents to your clipboard!