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The effects of human ANF 99-126 on the aldosterone and cortisol responses to ACTH infusion were studied in 8 normal volunteers. ACTH infusion caused a significant rise in aldosterone and cortisol on each study day. On the day that ANF was concomitantly infused the aldosterone, but not the cortisol, response to ACTH was significantly attenuated. These results show that a pharmacological dose of ANF selectively inhibits ACTH mediated mineralocorticoid as opposed to glucocorticoid release in man. These results support in vitro and in vivo findings from animal experiments. These findings also compliment previous studies showing that ANF inhibits ANG II stimulated aldosterone release in normal subjects.
J McMurray, and
W J Coutie, and
L McFarlane, and
A D Struthers
January 1992,
Life sciences,
J McMurray, and
W J Coutie, and
L McFarlane, and
A D Struthers
July 1991,
British journal of clinical pharmacology,
J McMurray, and
W J Coutie, and
L McFarlane, and
A D Struthers
January 1987,
The Journal of clinical endocrinology and metabolism,
J McMurray, and
W J Coutie, and
L McFarlane, and
A D Struthers
March 1996,
Aviation, space, and environmental medicine,
J McMurray, and
W J Coutie, and
L McFarlane, and
A D Struthers
February 1989,
Biochemical and biophysical research communications,
J McMurray, and
W J Coutie, and
L McFarlane, and
A D Struthers
May 1986,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
J McMurray, and
W J Coutie, and
L McFarlane, and
A D Struthers
October 1983,
Life sciences,
J McMurray, and
W J Coutie, and
L McFarlane, and
A D Struthers
October 1983,
Journal of endocrinological investigation,
J McMurray, and
W J Coutie, and
L McFarlane, and
A D Struthers
August 1992,
The Journal of clinical endocrinology and metabolism,
J McMurray, and
W J Coutie, and
L McFarlane, and
A D Struthers
January 1987,
Endocrinology,
