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The tubuloglomerular feedback (TGF) mechanism was evaluated in the nonclipped kidney of Goldblatt hypertensive rats from both stop flow pressure (SFP) and single nephron glomerular filtration rate (SNGFR) responses to step increases in late proximal perfusion rate from 0 to 40 nl/min. During control conditions, increases in late proximal perfusion rate produced flow dependent decreases in SFP and SNGFR with maximal values of 10.2 +/- 1.0 mm Hg and 12.9 +/- 2.5 nl/min, values similar to those obtained in normal rats. During ACE inhibition (MK 422; 0.6 mg/kg/hr), arterial pressure decreased from 168 +/- 8 to 137 +/- 7 mm Hg and there was a marked attenuation in the magnitude of SFP feedback responses (delta = 2.5 +/- 0.3 mm Hg). SNGFR feedback responses, however, were not significantly impaired. Direct decreases in renal arterial pressure reduced control SFP but SFP feedback responses were maintained, indicating that the attenuated SFP feedback responses during ACE inhibition were not due to decreased arterial pressure. Superimposed infusion of angiotensin II during ACE inhibition partially restored SFP feedback responses. In contrast, norepinephrine infusion did not result in a similar restoration of SFP feedback sensitivity. These results indicate that the nonclipped kidney of Goldblatt hypertensive rats has an intact TGF mechanism as assessed from SFP and SNGFR feedback responses. Furthermore, ACE inhibition attenuates SFP but not SNGFR feedback responses, and systemic angiotensin II infusions can restore SFP feedback responsiveness towards normal.
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L G Navar
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W C Huang, and
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W C Huang, and
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W C Huang, and
P D Bell, and
D Harvey, and
K D Mitchell, and
L G Navar
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W C Huang, and
P D Bell, and
D Harvey, and
K D Mitchell, and
L G Navar
June 1990,
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W C Huang, and
P D Bell, and
D Harvey, and
K D Mitchell, and
L G Navar
June 1991,
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W C Huang, and
P D Bell, and
D Harvey, and
K D Mitchell, and
L G Navar
February 1985,
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W C Huang, and
P D Bell, and
D Harvey, and
K D Mitchell, and
L G Navar
October 1977,
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W C Huang, and
P D Bell, and
D Harvey, and
K D Mitchell, and
L G Navar
June 1991,
Kidney international. Supplement,
W C Huang, and
P D Bell, and
D Harvey, and
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L G Navar
February 1993,
Anaesthesia and intensive care,
