Biomaterial Database

[Hormonal aspects of benign diseases of the breast]. 1988

M Görlich

Zentralinstitut für Krebsforschung, Akademie der Wissenschaften der DDR, Robert-Rössle-Institut, Berlin-Buch.

Basing on references from literature it has been looked for possibilities to characterize benign lesions of the breast by endocrine data and to find a discrimination between types connected with high or low risk for breast cancer. Conventional investigations of hormonal excretions and measurements of plasma contents only provide data for statistical evaluations which can not be used to assess the situation of an individual patient. Obviously one has to look for the processes of hormonal promotion on a cellular level. These processes are thought to realize a non-hormonal initial event to a benign or malignant disease. This requires finding of corresponding representative data. Some possibilities as receptor investigations or recording of hormone induced secretion proteins have been discussed.

UI	MeSH Term	Description	Entries
D011956	Receptors, Cell Surface	Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.	Cell Surface Receptor,Cell Surface Receptors,Hormone Receptors, Cell Surface,Receptors, Endogenous Substances,Cell Surface Hormone Receptors,Endogenous Substances Receptors,Receptor, Cell Surface,Surface Receptor, Cell
D001941	Breast Diseases	Pathological processes of the BREAST.	Endocrine Breast Diseases,Breast Disease,Breast Disease, Endocrine,Breast Diseases, Endocrine,Disease, Breast,Disease, Endocrine Breast,Diseases, Breast,Diseases, Endocrine Breast,Endocrine Breast Disease
D005260	Female		Females
D006728	Hormones	Chemical substances having a specific regulatory effect on the activity of a certain organ or organs. The term was originally applied to substances secreted by various ENDOCRINE GLANDS and transported in the bloodstream to the target organs. It is sometimes extended to include those substances that are not produced by the endocrine glands but that have similar effects.	Hormone,Hormone Receptor Agonists,Agonists, Hormone Receptor,Receptor Agonists, Hormone
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man