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Light chain Fanconi syndrome in a patient with acute myeloid leukemia and monoclonal gammopathy of undetermined significance. 2016
Daniel W Ross, and
Rimda Wanchoo, and
Adriana Guigova, and
Cristina Ghiuzeli, and
Steven L Allen, and
Kenar D Jhaveri
Division of Kidney Diseases and Hypertension, Department of Medicine, Hofstra Northwell School of Medicine, 450 Lakeville Road, Lake Success, NY, 11042, USA. dross@northwell.edu.
Proximal tubules are a target for paraproteinemic diseases. Cast nephropathy, light chain deposition diseases, and amyloidosis are frequently encountered in patients with multiple myeloma. Rarely, a subset of patients develop light chain Fanconi syndrome (LCFS). LCFS has been reported with multiple myeloma, monoclonal gammopathy of renal significance (MGRS), chronic lymphocytic leukemia, Waldenstrom's macroglobulinemia and diffuse large B-cell lymphoma. No cases have been described with other hematologic malignancies. We report the first case of lambda LCFS in a patient with both acute myeloid leukemia (AML) and monoclonal gammopathy of undetermined significance (MGUS).
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