Cerebellar Gray Matter Alterations in Huntington Disease: A Voxel-Based Morphometry Study. 2017

Paula C de Azevedo, and Rachel P Guimarães, and Camila C Piccinin, and Luiza G Piovesana, and Lidiane S Campos, and Juliana R Zuiani, and Eliza M Tamashiro, and Giordanna Pinheiro, and Augusto C Amato-Filho, and Fernando Cendes, and Iscia Lopes-Cendes, and Anelyssa D'Abreu
Neuroimaging Laboratory, University of Campinas UNICAMP, Campinas, Rua Vital Brasil, 251, Cidade Universitária Zeferino Vaz, Campinas, SP, 13083-887, Brazil. paulacazevedo@yahoo.com.br.

Neuropathological and neuroimaging studies in Huntington disease (HD) have suggested a role for the cerebellum. Our goal was to perform a detailed evaluation of cerebellar morphology. We performed the Unified HD rating scale (UHDRS) and Montreal cognitive assessment (MOCA) in 26 HD patients and 26 healthy controls. We created a two-sample test to analyze cerebellar gray matter (GM) differences between groups and another to correlate GM alterations with UHDRS and MOCA, corrected for age, expanded cytosine-adenine-guanine repeats, and disease duration using the spatially unbiased atlas template (SUIT)-SPM-toolbox which preserves anatomical detailing. We found increased GM density in the anterior cerebellum compared to controls. Higher GM density in the postero-superior lobe correlated with mood symptoms. Worse motor function and better cognitive function correlated with GM changes in the posterior cerebellum (false discovery rate (FDR) correction p < 0.05 and k > 100 voxels). In this detailed study of the in vivo cerebellar morphology in HD, we observed GM changes in regions involved in sensorimotor integration, motor planning, and emotional processing, supporting cerebellar involvement in the neuropathological process of HD.

UI MeSH Term Description Entries
D007091 Image Processing, Computer-Assisted A technique of inputting two-dimensional or three-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer. Biomedical Image Processing,Computer-Assisted Image Processing,Digital Image Processing,Image Analysis, Computer-Assisted,Image Reconstruction,Medical Image Processing,Analysis, Computer-Assisted Image,Computer-Assisted Image Analysis,Computer Assisted Image Analysis,Computer Assisted Image Processing,Computer-Assisted Image Analyses,Image Analyses, Computer-Assisted,Image Analysis, Computer Assisted,Image Processing, Biomedical,Image Processing, Computer Assisted,Image Processing, Digital,Image Processing, Medical,Image Processings, Medical,Image Reconstructions,Medical Image Processings,Processing, Biomedical Image,Processing, Digital Image,Processing, Medical Image,Processings, Digital Image,Processings, Medical Image,Reconstruction, Image,Reconstructions, Image
D008279 Magnetic Resonance Imaging Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques. Chemical Shift Imaging,MR Tomography,MRI Scans,MRI, Functional,Magnetic Resonance Image,Magnetic Resonance Imaging, Functional,Magnetization Transfer Contrast Imaging,NMR Imaging,NMR Tomography,Tomography, NMR,Tomography, Proton Spin,fMRI,Functional Magnetic Resonance Imaging,Imaging, Chemical Shift,Proton Spin Tomography,Spin Echo Imaging,Steady-State Free Precession MRI,Tomography, MR,Zeugmatography,Chemical Shift Imagings,Echo Imaging, Spin,Echo Imagings, Spin,Functional MRI,Functional MRIs,Image, Magnetic Resonance,Imaging, Magnetic Resonance,Imaging, NMR,Imaging, Spin Echo,Imagings, Chemical Shift,Imagings, Spin Echo,MRI Scan,MRIs, Functional,Magnetic Resonance Images,Resonance Image, Magnetic,Scan, MRI,Scans, MRI,Shift Imaging, Chemical,Shift Imagings, Chemical,Spin Echo Imagings,Steady State Free Precession MRI
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D002531 Cerebellum The part of brain that lies behind the BRAIN STEM in the posterior base of skull (CRANIAL FOSSA, POSTERIOR). It is also known as the "little brain" with convolutions similar to those of CEREBRAL CORTEX, inner white matter, and deep cerebellar nuclei. Its function is to coordinate voluntary movements, maintain balance, and learn motor skills. Cerebella,Corpus Cerebelli,Parencephalon,Cerebellums,Parencephalons
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006816 Huntington Disease A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4) Huntington Chorea,Juvenile Huntington Disease,Akinetic-Rigid Variant of Huntington Disease,Chorea, Chronic Progressive Hereditary (Huntington),Chronic Progressive Hereditary Chorea (Huntington),Huntington Chronic Progressive Hereditary Chorea,Huntington Disease, Akinetic-Rigid Variant,Huntington Disease, Juvenile,Huntington Disease, Juvenile-Onset,Huntington Disease, Late Onset,Huntington's Chorea,Huntington's Disease,Juvenile-Onset Huntington Disease,Late-Onset Huntington Disease,Progressive Chorea, Chronic Hereditary (Huntington),Progressive Chorea, Hereditary, Chronic (Huntington),Akinetic Rigid Variant of Huntington Disease,Chorea, Huntington,Chorea, Huntington's,Huntington Disease, Akinetic Rigid Variant,Huntington Disease, Juvenile Onset,Huntington Disease, Late-Onset,Juvenile Onset Huntington Disease,Late Onset Huntington Disease
D000375 Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time. Senescence,Aging, Biological,Biological Aging
D012720 Severity of Illness Index Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder. Illness Index Severities,Illness Index Severity

Related Publications

Paula C de Azevedo, and Rachel P Guimarães, and Camila C Piccinin, and Luiza G Piovesana, and Lidiane S Campos, and Juliana R Zuiani, and Eliza M Tamashiro, and Giordanna Pinheiro, and Augusto C Amato-Filho, and Fernando Cendes, and Iscia Lopes-Cendes, and Anelyssa D'Abreu
April 2017, Scientific reports,
Paula C de Azevedo, and Rachel P Guimarães, and Camila C Piccinin, and Luiza G Piovesana, and Lidiane S Campos, and Juliana R Zuiani, and Eliza M Tamashiro, and Giordanna Pinheiro, and Augusto C Amato-Filho, and Fernando Cendes, and Iscia Lopes-Cendes, and Anelyssa D'Abreu
January 2015, Neurological research,
Paula C de Azevedo, and Rachel P Guimarães, and Camila C Piccinin, and Luiza G Piovesana, and Lidiane S Campos, and Juliana R Zuiani, and Eliza M Tamashiro, and Giordanna Pinheiro, and Augusto C Amato-Filho, and Fernando Cendes, and Iscia Lopes-Cendes, and Anelyssa D'Abreu
January 2022, Scientific reports,
Paula C de Azevedo, and Rachel P Guimarães, and Camila C Piccinin, and Luiza G Piovesana, and Lidiane S Campos, and Juliana R Zuiani, and Eliza M Tamashiro, and Giordanna Pinheiro, and Augusto C Amato-Filho, and Fernando Cendes, and Iscia Lopes-Cendes, and Anelyssa D'Abreu
March 2025, Pain physician,
Paula C de Azevedo, and Rachel P Guimarães, and Camila C Piccinin, and Luiza G Piovesana, and Lidiane S Campos, and Juliana R Zuiani, and Eliza M Tamashiro, and Giordanna Pinheiro, and Augusto C Amato-Filho, and Fernando Cendes, and Iscia Lopes-Cendes, and Anelyssa D'Abreu
July 2011, European journal of radiology,
Paula C de Azevedo, and Rachel P Guimarães, and Camila C Piccinin, and Luiza G Piovesana, and Lidiane S Campos, and Juliana R Zuiani, and Eliza M Tamashiro, and Giordanna Pinheiro, and Augusto C Amato-Filho, and Fernando Cendes, and Iscia Lopes-Cendes, and Anelyssa D'Abreu
January 2024, Epilepsia,
Paula C de Azevedo, and Rachel P Guimarães, and Camila C Piccinin, and Luiza G Piovesana, and Lidiane S Campos, and Juliana R Zuiani, and Eliza M Tamashiro, and Giordanna Pinheiro, and Augusto C Amato-Filho, and Fernando Cendes, and Iscia Lopes-Cendes, and Anelyssa D'Abreu
January 2003, Neurobiology of aging,
Paula C de Azevedo, and Rachel P Guimarães, and Camila C Piccinin, and Luiza G Piovesana, and Lidiane S Campos, and Juliana R Zuiani, and Eliza M Tamashiro, and Giordanna Pinheiro, and Augusto C Amato-Filho, and Fernando Cendes, and Iscia Lopes-Cendes, and Anelyssa D'Abreu
January 2022, Frontiers in psychiatry,
Paula C de Azevedo, and Rachel P Guimarães, and Camila C Piccinin, and Luiza G Piovesana, and Lidiane S Campos, and Juliana R Zuiani, and Eliza M Tamashiro, and Giordanna Pinheiro, and Augusto C Amato-Filho, and Fernando Cendes, and Iscia Lopes-Cendes, and Anelyssa D'Abreu
October 2013, Neuroscience letters,
Paula C de Azevedo, and Rachel P Guimarães, and Camila C Piccinin, and Luiza G Piovesana, and Lidiane S Campos, and Juliana R Zuiani, and Eliza M Tamashiro, and Giordanna Pinheiro, and Augusto C Amato-Filho, and Fernando Cendes, and Iscia Lopes-Cendes, and Anelyssa D'Abreu
July 2011, Journal of attention disorders,
Copied contents to your clipboard!