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Visualization of vesicular transport from the endoplasmic reticulum to lysosome using an amidine derived two-photon probe. 2017

Hyo Won Lee, and Myoung Ki Cho, and Hye-Ri Kim, and Chang Su Lim, and Chulhun Kang, and Hwan Myung Kim
Department of Energy Systems Research and Department of Chemistry, Ajou University, Suwon 443-749, Korea. kimhm@ajou.ac.kr.

We report an amidine-based small molecule two-photon fluorescent probe (ELP1) for monitoring vesicle transport from the ER to lysosome in live cells. Two-photon microscopy imaging studies indicated that this probe initially localized in the ER and subsequently transferred to lysosomal compartments through vesicular transport. These results may provide an effective tool for studying trafficking-related biology and pathology in real-time.

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