Excretory/secretory products from the gastrointestinal nematode Trichuris muris. 2017

Lucienne Tritten, and Mifong Tam, and Mireille Vargas, and Armando Jardim, and Mary M Stevenson, and Jennifer Keiser, and Timothy G Geary
Institute of Parasitology, McGill University, 21,111 Lakeshore Road, Sainte-Anne-de-Bellevue, Quebec H9X 3V9, Canada; Centre for Host-Parasite Interactions, Canada. Electronic address: lucienne.tritten@uzh.ch.

To better control gastrointestinal nematode infections in humans and animals, it is important to understand the strategies used by these parasites to modulate the host immune system. In this regard, molecules released by parasites have been attributed crucially important roles in host-parasite negotiations. We characterized the excretory/secretory (E/S) microRNA (miRNA) and protein profiles from the mouse gastrointestinal nematode parasite Trichuris muris. Released miRNAs were subjected to miRNA sequencing and E/S proteins were analysed by mass spectrometry. Fourteen miRNAs were identified in T. muris exosome-like vesicles, as well as 73 proteins of nematode origin, 11 of which were unique to this study. Comparison with published nematode protein secretomes revealed high conservation at the functional level.

UI MeSH Term Description Entries
D003470 Culture Media Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN. Media, Culture
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014258 Trichuris A genus of nematode worms comprising the whipworms. Trichocephalus,Trichuris trichiura,Trichuri,Trichuris trichiuras,trichiura, Trichuris
D015203 Reproducibility of Results The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results. Reliability and Validity,Reliability of Result,Reproducibility Of Result,Reproducibility of Finding,Validity of Result,Validity of Results,Face Validity,Reliability (Epidemiology),Reliability of Results,Reproducibility of Findings,Test-Retest Reliability,Validity (Epidemiology),Finding Reproducibilities,Finding Reproducibility,Of Result, Reproducibility,Of Results, Reproducibility,Reliabilities, Test-Retest,Reliability, Test-Retest,Result Reliabilities,Result Reliability,Result Validities,Result Validity,Result, Reproducibility Of,Results, Reproducibility Of,Test Retest Reliability,Validity and Reliability,Validity, Face
D015801 Helminth Proteins Proteins found in any species of helminth. Helminth Protein,Protein, Helminth,Proteins, Helminth
D055354 Exosomes A type of extracellular vesicle, containing RNA and proteins, that is secreted into the extracellular space by EXOCYTOSIS when MULTIVESICULAR BODIES fuse with the PLASMA MEMBRANE.
D035683 MicroRNAs Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing. RNA, Small Temporal,Small Temporal RNA,miRNA,stRNA,Micro RNA,MicroRNA,Primary MicroRNA,Primary miRNA,miRNAs,pre-miRNA,pri-miRNA,MicroRNA, Primary,RNA, Micro,Temporal RNA, Small,miRNA, Primary,pre miRNA,pri miRNA
D040901 Proteomics The systematic study of the complete complement of proteins (PROTEOME) of organisms. Peptidomics

Related Publications

Lucienne Tritten, and Mifong Tam, and Mireille Vargas, and Armando Jardim, and Mary M Stevenson, and Jennifer Keiser, and Timothy G Geary
September 1990, Parasite immunology,
Lucienne Tritten, and Mifong Tam, and Mireille Vargas, and Armando Jardim, and Mary M Stevenson, and Jennifer Keiser, and Timothy G Geary
September 2001, Experimental parasitology,
Lucienne Tritten, and Mifong Tam, and Mireille Vargas, and Armando Jardim, and Mary M Stevenson, and Jennifer Keiser, and Timothy G Geary
December 2014, Nature protocols,
Lucienne Tritten, and Mifong Tam, and Mireille Vargas, and Armando Jardim, and Mary M Stevenson, and Jennifer Keiser, and Timothy G Geary
March 2018, Scientific reports,
Lucienne Tritten, and Mifong Tam, and Mireille Vargas, and Armando Jardim, and Mary M Stevenson, and Jennifer Keiser, and Timothy G Geary
February 2009, Immunology,
Lucienne Tritten, and Mifong Tam, and Mireille Vargas, and Armando Jardim, and Mary M Stevenson, and Jennifer Keiser, and Timothy G Geary
August 1983, International journal for parasitology,
Lucienne Tritten, and Mifong Tam, and Mireille Vargas, and Armando Jardim, and Mary M Stevenson, and Jennifer Keiser, and Timothy G Geary
June 2001, Infection and immunity,
Lucienne Tritten, and Mifong Tam, and Mireille Vargas, and Armando Jardim, and Mary M Stevenson, and Jennifer Keiser, and Timothy G Geary
August 1998, Infection and immunity,
Lucienne Tritten, and Mifong Tam, and Mireille Vargas, and Armando Jardim, and Mary M Stevenson, and Jennifer Keiser, and Timothy G Geary
June 2010, Science (New York, N.Y.),
Lucienne Tritten, and Mifong Tam, and Mireille Vargas, and Armando Jardim, and Mary M Stevenson, and Jennifer Keiser, and Timothy G Geary
March 1999, European journal of biochemistry,
Copied contents to your clipboard!