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The characteristics and consequences of limbic seizures evoked by single peripheral injections of lithium (3 mEq/kg) and pilocarpine (30 mg/kg) were investigated over a three-year period. The seizures occurred when 3 mEq/kg of lithium was followed 4 to 28 hours later by 30 mg/kg of pilocarpine. The seizures did not occur if the intervals were shorter or longer or if the pilocarpine preceded the lithium. The acute mortality or persistent aphagia and adipsia could be compensated by postseizure injections of acepromazine and a special milk-bread diet. Gender, age and preinjection environmental effects, but not hybrid genetics, influenced the seizure onset latency. Fifty to 100 days after the seizures massive lesions were found in the entorhinal-pyriform cortices, amygdala and selected thalamic groups.
M A Persinger, and
K Makarec, and
J C Bradley
September 1992,
Pharmacology, biochemistry, and behavior,
M A Persinger, and
K Makarec, and
J C Bradley
May 1993,
Physiology & behavior,
M A Persinger, and
K Makarec, and
J C Bradley
June 1998,
Perceptual and motor skills,
M A Persinger, and
K Makarec, and
J C Bradley
July 1988,
Neuroscience letters,
M A Persinger, and
K Makarec, and
J C Bradley
September 1983,
Behavioural brain research,
M A Persinger, and
K Makarec, and
J C Bradley
December 1987,
Neuroscience,
M A Persinger, and
K Makarec, and
J C Bradley
June 1995,
Neuroscience letters,
M A Persinger, and
K Makarec, and
J C Bradley
August 1966,
Electroencephalography and clinical neurophysiology,
M A Persinger, and
K Makarec, and
J C Bradley
April 1997,
Brain research,
M A Persinger, and
K Makarec, and
J C Bradley
January 2007,
Neuroscience and biobehavioral reviews,
