-transparent.png){kind=logo}
A robust and high-yielding radiochemical synthesis of 11C-N-cyanobenzamides using a palladium-mediated aminocarbonylation with 11C-CO, aryl halides and cyanamide is described. The bidentate ligand 1,1'-bis(diphenylphosphino)ferrocene provided 11C-N-cyanobenzamides from aryl-iodides, bromides, triflates and even chlorides in 28-79% radiochemical yield after semi-preparative HPLC. To further highlight the utility of this method, novel 11C-N-cyanobenzamide analogs of flufenamic acid, meflanamic acid, dazoxiben and tamibarotene were synthesized in 34-71% radiochemical yields.
Related Publications
P Nordeman, and
S Y Chow, and
A F Odell, and
G Antoni, and
L R Odell
September 2014,
Angewandte Chemie (International ed. in English),
P Nordeman, and
S Y Chow, and
A F Odell, and
G Antoni, and
L R Odell
November 2010,
Journal of the American Chemical Society,
P Nordeman, and
S Y Chow, and
A F Odell, and
G Antoni, and
L R Odell
January 2023,
Current organic synthesis,
P Nordeman, and
S Y Chow, and
A F Odell, and
G Antoni, and
L R Odell
January 2022,
Beilstein journal of organic chemistry,
P Nordeman, and
S Y Chow, and
A F Odell, and
G Antoni, and
L R Odell
January 2009,
Angewandte Chemie (International ed. in English),
P Nordeman, and
S Y Chow, and
A F Odell, and
G Antoni, and
L R Odell
June 2020,
Organic & biomolecular chemistry,
P Nordeman, and
S Y Chow, and
A F Odell, and
G Antoni, and
L R Odell
January 2009,
Chemical communications (Cambridge, England),
P Nordeman, and
S Y Chow, and
A F Odell, and
G Antoni, and
L R Odell
November 2023,
Organic letters,
P Nordeman, and
S Y Chow, and
A F Odell, and
G Antoni, and
L R Odell
February 2011,
Chemical communications (Cambridge, England),
P Nordeman, and
S Y Chow, and
A F Odell, and
G Antoni, and
L R Odell
June 2021,
Organic & biomolecular chemistry,
