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Zika virus evolution and spread in the Americas. 2017
Hayden C Metsky, and
Christian B Matranga, and
Shirlee Wohl, and
Stephen F Schaffner, and
Catherine A Freije, and
Sarah M Winnicki, and
Kendra West, and
James Qu, and
Mary Lynn Baniecki, and
Adrianne Gladden-Young, and
Aaron E Lin, and
Christopher H Tomkins-Tinch, and
Simon H Ye, and
Daniel J Park, and
Cynthia Y Luo, and
Kayla G Barnes, and
Rickey R Shah, and
Bridget Chak, and
Giselle Barbosa-Lima, and
Edson Delatorre, and
Yasmine R Vieira, and
Lauren M Paul, and
Amanda L Tan, and
Carolyn M Barcellona, and
Mario C Porcelli, and
Chalmers Vasquez, and
Andrew C Cannons, and
Marshall R Cone, and
Kelly N Hogan, and
Edgar W Kopp, and
Joshua J Anzinger, and
Kimberly F Garcia, and
Leda A Parham, and
Rosa M Gélvez Ramírez, and
Maria C Miranda Montoya, and
Diana P Rojas, and
Catherine M Brown, and
Scott Hennigan, and
Brandon Sabina, and
Sarah Scotland, and
Karthik Gangavarapu, and
Nathan D Grubaugh, and
Glenn Oliveira, and
Refugio Robles-Sikisaka, and
Andrew Rambaut, and
Lee Gehrke, and
Sandra Smole, and
M Elizabeth Halloran, and
Luis Villar, and
Salim Mattar, and
Ivette Lorenzana, and
Jose Cerbino-Neto, and
Clarissa Valim, and
Wim Degrave, and
Patricia T Bozza, and
Andreas Gnirke, and
Kristian G Andersen, and
Sharon Isern, and
Scott F Michael, and
Fernando A Bozza, and
Thiago M L Souza, and
Irene Bosch, and
Nathan L Yozwiak, and
Bronwyn L MacInnis, and
Pardis C Sabeti
Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Although the recent Zika virus (ZIKV) epidemic in the Americas and its link to birth defects have attracted a great deal of attention, much remains unknown about ZIKV disease epidemiology and ZIKV evolution, in part owing to a lack of genomic data. Here we address this gap in knowledge by using multiple sequencing approaches to generate 110 ZIKV genomes from clinical and mosquito samples from 10 countries and territories, greatly expanding the observed viral genetic diversity from this outbreak. We analysed the timing and patterns of introductions into distinct geographic regions; our phylogenetic evidence suggests rapid expansion of the outbreak in Brazil and multiple introductions of outbreak strains into Puerto Rico, Honduras, Colombia, other Caribbean islands, and the continental United States. We find that ZIKV circulated undetected in multiple regions for many months before the first locally transmitted cases were confirmed, highlighting the importance of surveillance of viral infections. We identify mutations with possible functional implications for ZIKV biology and pathogenesis, as well as those that might be relevant to the effectiveness of diagnostic tests.
Related Publications
Hayden C Metsky, and
Christian B Matranga, and
Shirlee Wohl, and
Stephen F Schaffner, and
Catherine A Freije, and
Sarah M Winnicki, and
Kendra West, and
James Qu, and
Mary Lynn Baniecki, and
Adrianne Gladden-Young, and
Aaron E Lin, and
Christopher H Tomkins-Tinch, and
Simon H Ye, and
Daniel J Park, and
Cynthia Y Luo, and
Kayla G Barnes, and
Rickey R Shah, and
Bridget Chak, and
Giselle Barbosa-Lima, and
Edson Delatorre, and
Yasmine R Vieira, and
Lauren M Paul, and
Amanda L Tan, and
Carolyn M Barcellona, and
Mario C Porcelli, and
Chalmers Vasquez, and
Andrew C Cannons, and
Marshall R Cone, and
Kelly N Hogan, and
Edgar W Kopp, and
Joshua J Anzinger, and
Kimberly F Garcia, and
Leda A Parham, and
Rosa M Gélvez Ramírez, and
Maria C Miranda Montoya, and
Diana P Rojas, and
Catherine M Brown, and
Scott Hennigan, and
Brandon Sabina, and
Sarah Scotland, and
Karthik Gangavarapu, and
Nathan D Grubaugh, and
Glenn Oliveira, and
Refugio Robles-Sikisaka, and
Andrew Rambaut, and
Lee Gehrke, and
Sandra Smole, and
M Elizabeth Halloran, and
Luis Villar, and
Salim Mattar, and
Ivette Lorenzana, and
Jose Cerbino-Neto, and
Clarissa Valim, and
Wim Degrave, and
Patricia T Bozza, and
Andreas Gnirke, and
Kristian G Andersen, and
Sharon Isern, and
Scott F Michael, and
Fernando A Bozza, and
Thiago M L Souza, and
Irene Bosch, and
Nathan L Yozwiak, and
Bronwyn L MacInnis, and
Pardis C Sabeti
May 2017,
Proceedings of the National Academy of Sciences of the United States of America,
Hayden C Metsky, and
Christian B Matranga, and
Shirlee Wohl, and
Stephen F Schaffner, and
Catherine A Freije, and
Sarah M Winnicki, and
Kendra West, and
James Qu, and
Mary Lynn Baniecki, and
Adrianne Gladden-Young, and
Aaron E Lin, and
Christopher H Tomkins-Tinch, and
Simon H Ye, and
Daniel J Park, and
Cynthia Y Luo, and
Kayla G Barnes, and
Rickey R Shah, and
Bridget Chak, and
Giselle Barbosa-Lima, and
Edson Delatorre, and
Yasmine R Vieira, and
Lauren M Paul, and
Amanda L Tan, and
Carolyn M Barcellona, and
Mario C Porcelli, and
Chalmers Vasquez, and
Andrew C Cannons, and
Marshall R Cone, and
Kelly N Hogan, and
Edgar W Kopp, and
Joshua J Anzinger, and
Kimberly F Garcia, and
Leda A Parham, and
Rosa M Gélvez Ramírez, and
Maria C Miranda Montoya, and
Diana P Rojas, and
Catherine M Brown, and
Scott Hennigan, and
Brandon Sabina, and
Sarah Scotland, and
Karthik Gangavarapu, and
Nathan D Grubaugh, and
Glenn Oliveira, and
Refugio Robles-Sikisaka, and
Andrew Rambaut, and
Lee Gehrke, and
Sandra Smole, and
M Elizabeth Halloran, and
Luis Villar, and
Salim Mattar, and
Ivette Lorenzana, and
Jose Cerbino-Neto, and
Clarissa Valim, and
Wim Degrave, and
Patricia T Bozza, and
Andreas Gnirke, and
Kristian G Andersen, and
Sharon Isern, and
Scott F Michael, and
Fernando A Bozza, and
Thiago M L Souza, and
Irene Bosch, and
Nathan L Yozwiak, and
Bronwyn L MacInnis, and
Pardis C Sabeti
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Nature reviews. Microbiology,
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Christian B Matranga, and
Shirlee Wohl, and
Stephen F Schaffner, and
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Kendra West, and
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Mary Lynn Baniecki, and
Adrianne Gladden-Young, and
Aaron E Lin, and
Christopher H Tomkins-Tinch, and
Simon H Ye, and
Daniel J Park, and
Cynthia Y Luo, and
Kayla G Barnes, and
Rickey R Shah, and
Bridget Chak, and
Giselle Barbosa-Lima, and
Edson Delatorre, and
Yasmine R Vieira, and
Lauren M Paul, and
Amanda L Tan, and
Carolyn M Barcellona, and
Mario C Porcelli, and
Chalmers Vasquez, and
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Marshall R Cone, and
Kelly N Hogan, and
Edgar W Kopp, and
Joshua J Anzinger, and
Kimberly F Garcia, and
Leda A Parham, and
Rosa M Gélvez Ramírez, and
Maria C Miranda Montoya, and
Diana P Rojas, and
Catherine M Brown, and
Scott Hennigan, and
Brandon Sabina, and
Sarah Scotland, and
Karthik Gangavarapu, and
Nathan D Grubaugh, and
Glenn Oliveira, and
Refugio Robles-Sikisaka, and
Andrew Rambaut, and
Lee Gehrke, and
Sandra Smole, and
M Elizabeth Halloran, and
Luis Villar, and
Salim Mattar, and
Ivette Lorenzana, and
Jose Cerbino-Neto, and
Clarissa Valim, and
Wim Degrave, and
Patricia T Bozza, and
Andreas Gnirke, and
Kristian G Andersen, and
Sharon Isern, and
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Fernando A Bozza, and
Thiago M L Souza, and
Irene Bosch, and
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Bronwyn L MacInnis, and
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Hayden C Metsky, and
Christian B Matranga, and
Shirlee Wohl, and
Stephen F Schaffner, and
Catherine A Freije, and
Sarah M Winnicki, and
Kendra West, and
James Qu, and
Mary Lynn Baniecki, and
Adrianne Gladden-Young, and
Aaron E Lin, and
Christopher H Tomkins-Tinch, and
Simon H Ye, and
Daniel J Park, and
Cynthia Y Luo, and
Kayla G Barnes, and
Rickey R Shah, and
Bridget Chak, and
Giselle Barbosa-Lima, and
Edson Delatorre, and
Yasmine R Vieira, and
Lauren M Paul, and
Amanda L Tan, and
Carolyn M Barcellona, and
Mario C Porcelli, and
Chalmers Vasquez, and
Andrew C Cannons, and
Marshall R Cone, and
Kelly N Hogan, and
Edgar W Kopp, and
Joshua J Anzinger, and
Kimberly F Garcia, and
Leda A Parham, and
Rosa M Gélvez Ramírez, and
Maria C Miranda Montoya, and
Diana P Rojas, and
Catherine M Brown, and
Scott Hennigan, and
Brandon Sabina, and
Sarah Scotland, and
Karthik Gangavarapu, and
Nathan D Grubaugh, and
Glenn Oliveira, and
Refugio Robles-Sikisaka, and
Andrew Rambaut, and
Lee Gehrke, and
Sandra Smole, and
M Elizabeth Halloran, and
Luis Villar, and
Salim Mattar, and
Ivette Lorenzana, and
Jose Cerbino-Neto, and
Clarissa Valim, and
Wim Degrave, and
Patricia T Bozza, and
Andreas Gnirke, and
Kristian G Andersen, and
Sharon Isern, and
Scott F Michael, and
Fernando A Bozza, and
Thiago M L Souza, and
Irene Bosch, and
Nathan L Yozwiak, and
Bronwyn L MacInnis, and
Pardis C Sabeti
November 2015,
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Christian B Matranga, and
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Catherine A Freije, and
Sarah M Winnicki, and
Kendra West, and
James Qu, and
Mary Lynn Baniecki, and
Adrianne Gladden-Young, and
Aaron E Lin, and
Christopher H Tomkins-Tinch, and
Simon H Ye, and
Daniel J Park, and
Cynthia Y Luo, and
Kayla G Barnes, and
Rickey R Shah, and
Bridget Chak, and
Giselle Barbosa-Lima, and
Edson Delatorre, and
Yasmine R Vieira, and
Lauren M Paul, and
Amanda L Tan, and
Carolyn M Barcellona, and
Mario C Porcelli, and
Chalmers Vasquez, and
Andrew C Cannons, and
Marshall R Cone, and
Kelly N Hogan, and
Edgar W Kopp, and
Joshua J Anzinger, and
Kimberly F Garcia, and
Leda A Parham, and
Rosa M Gélvez Ramírez, and
Maria C Miranda Montoya, and
Diana P Rojas, and
Catherine M Brown, and
Scott Hennigan, and
Brandon Sabina, and
Sarah Scotland, and
Karthik Gangavarapu, and
Nathan D Grubaugh, and
Glenn Oliveira, and
Refugio Robles-Sikisaka, and
Andrew Rambaut, and
Lee Gehrke, and
Sandra Smole, and
M Elizabeth Halloran, and
Luis Villar, and
Salim Mattar, and
Ivette Lorenzana, and
Jose Cerbino-Neto, and
Clarissa Valim, and
Wim Degrave, and
Patricia T Bozza, and
Andreas Gnirke, and
Kristian G Andersen, and
Sharon Isern, and
Scott F Michael, and
Fernando A Bozza, and
Thiago M L Souza, and
Irene Bosch, and
Nathan L Yozwiak, and
Bronwyn L MacInnis, and
Pardis C Sabeti
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Hayden C Metsky, and
Christian B Matranga, and
Shirlee Wohl, and
Stephen F Schaffner, and
Catherine A Freije, and
Sarah M Winnicki, and
Kendra West, and
James Qu, and
Mary Lynn Baniecki, and
Adrianne Gladden-Young, and
Aaron E Lin, and
Christopher H Tomkins-Tinch, and
Simon H Ye, and
Daniel J Park, and
Cynthia Y Luo, and
Kayla G Barnes, and
Rickey R Shah, and
Bridget Chak, and
Giselle Barbosa-Lima, and
Edson Delatorre, and
Yasmine R Vieira, and
Lauren M Paul, and
Amanda L Tan, and
Carolyn M Barcellona, and
Mario C Porcelli, and
Chalmers Vasquez, and
Andrew C Cannons, and
Marshall R Cone, and
Kelly N Hogan, and
Edgar W Kopp, and
Joshua J Anzinger, and
Kimberly F Garcia, and
Leda A Parham, and
Rosa M Gélvez Ramírez, and
Maria C Miranda Montoya, and
Diana P Rojas, and
Catherine M Brown, and
Scott Hennigan, and
Brandon Sabina, and
Sarah Scotland, and
Karthik Gangavarapu, and
Nathan D Grubaugh, and
Glenn Oliveira, and
Refugio Robles-Sikisaka, and
Andrew Rambaut, and
Lee Gehrke, and
Sandra Smole, and
M Elizabeth Halloran, and
Luis Villar, and
Salim Mattar, and
Ivette Lorenzana, and
Jose Cerbino-Neto, and
Clarissa Valim, and
Wim Degrave, and
Patricia T Bozza, and
Andreas Gnirke, and
Kristian G Andersen, and
Sharon Isern, and
Scott F Michael, and
Fernando A Bozza, and
Thiago M L Souza, and
Irene Bosch, and
Nathan L Yozwiak, and
Bronwyn L MacInnis, and
Pardis C Sabeti
January 2016,
Lancet (London, England),
Hayden C Metsky, and
Christian B Matranga, and
Shirlee Wohl, and
Stephen F Schaffner, and
Catherine A Freije, and
Sarah M Winnicki, and
Kendra West, and
James Qu, and
Mary Lynn Baniecki, and
Adrianne Gladden-Young, and
Aaron E Lin, and
Christopher H Tomkins-Tinch, and
Simon H Ye, and
Daniel J Park, and
Cynthia Y Luo, and
Kayla G Barnes, and
Rickey R Shah, and
Bridget Chak, and
Giselle Barbosa-Lima, and
Edson Delatorre, and
Yasmine R Vieira, and
Lauren M Paul, and
Amanda L Tan, and
Carolyn M Barcellona, and
Mario C Porcelli, and
Chalmers Vasquez, and
Andrew C Cannons, and
Marshall R Cone, and
Kelly N Hogan, and
Edgar W Kopp, and
Joshua J Anzinger, and
Kimberly F Garcia, and
Leda A Parham, and
Rosa M Gélvez Ramírez, and
Maria C Miranda Montoya, and
Diana P Rojas, and
Catherine M Brown, and
Scott Hennigan, and
Brandon Sabina, and
Sarah Scotland, and
Karthik Gangavarapu, and
Nathan D Grubaugh, and
Glenn Oliveira, and
Refugio Robles-Sikisaka, and
Andrew Rambaut, and
Lee Gehrke, and
Sandra Smole, and
M Elizabeth Halloran, and
Luis Villar, and
Salim Mattar, and
Ivette Lorenzana, and
Jose Cerbino-Neto, and
Clarissa Valim, and
Wim Degrave, and
Patricia T Bozza, and
Andreas Gnirke, and
Kristian G Andersen, and
Sharon Isern, and
Scott F Michael, and
Fernando A Bozza, and
Thiago M L Souza, and
Irene Bosch, and
Nathan L Yozwiak, and
Bronwyn L MacInnis, and
Pardis C Sabeti
February 2017,
Cladistics : the international journal of the Willi Hennig Society,
Hayden C Metsky, and
Christian B Matranga, and
Shirlee Wohl, and
Stephen F Schaffner, and
Catherine A Freije, and
Sarah M Winnicki, and
Kendra West, and
James Qu, and
Mary Lynn Baniecki, and
Adrianne Gladden-Young, and
Aaron E Lin, and
Christopher H Tomkins-Tinch, and
Simon H Ye, and
Daniel J Park, and
Cynthia Y Luo, and
Kayla G Barnes, and
Rickey R Shah, and
Bridget Chak, and
Giselle Barbosa-Lima, and
Edson Delatorre, and
Yasmine R Vieira, and
Lauren M Paul, and
Amanda L Tan, and
Carolyn M Barcellona, and
Mario C Porcelli, and
Chalmers Vasquez, and
Andrew C Cannons, and
Marshall R Cone, and
Kelly N Hogan, and
Edgar W Kopp, and
Joshua J Anzinger, and
Kimberly F Garcia, and
Leda A Parham, and
Rosa M Gélvez Ramírez, and
Maria C Miranda Montoya, and
Diana P Rojas, and
Catherine M Brown, and
Scott Hennigan, and
Brandon Sabina, and
Sarah Scotland, and
Karthik Gangavarapu, and
Nathan D Grubaugh, and
Glenn Oliveira, and
Refugio Robles-Sikisaka, and
Andrew Rambaut, and
Lee Gehrke, and
Sandra Smole, and
M Elizabeth Halloran, and
Luis Villar, and
Salim Mattar, and
Ivette Lorenzana, and
Jose Cerbino-Neto, and
Clarissa Valim, and
Wim Degrave, and
Patricia T Bozza, and
Andreas Gnirke, and
Kristian G Andersen, and
Sharon Isern, and
Scott F Michael, and
Fernando A Bozza, and
Thiago M L Souza, and
Irene Bosch, and
Nathan L Yozwiak, and
Bronwyn L MacInnis, and
Pardis C Sabeti
October 2016,
Annals of internal medicine,
Hayden C Metsky, and
Christian B Matranga, and
Shirlee Wohl, and
Stephen F Schaffner, and
Catherine A Freije, and
Sarah M Winnicki, and
Kendra West, and
James Qu, and
Mary Lynn Baniecki, and
Adrianne Gladden-Young, and
Aaron E Lin, and
Christopher H Tomkins-Tinch, and
Simon H Ye, and
Daniel J Park, and
Cynthia Y Luo, and
Kayla G Barnes, and
Rickey R Shah, and
Bridget Chak, and
Giselle Barbosa-Lima, and
Edson Delatorre, and
Yasmine R Vieira, and
Lauren M Paul, and
Amanda L Tan, and
Carolyn M Barcellona, and
Mario C Porcelli, and
Chalmers Vasquez, and
Andrew C Cannons, and
Marshall R Cone, and
Kelly N Hogan, and
Edgar W Kopp, and
Joshua J Anzinger, and
Kimberly F Garcia, and
Leda A Parham, and
Rosa M Gélvez Ramírez, and
Maria C Miranda Montoya, and
Diana P Rojas, and
Catherine M Brown, and
Scott Hennigan, and
Brandon Sabina, and
Sarah Scotland, and
Karthik Gangavarapu, and
Nathan D Grubaugh, and
Glenn Oliveira, and
Refugio Robles-Sikisaka, and
Andrew Rambaut, and
Lee Gehrke, and
Sandra Smole, and
M Elizabeth Halloran, and
Luis Villar, and
Salim Mattar, and
Ivette Lorenzana, and
Jose Cerbino-Neto, and
Clarissa Valim, and
Wim Degrave, and
Patricia T Bozza, and
Andreas Gnirke, and
Kristian G Andersen, and
Sharon Isern, and
Scott F Michael, and
Fernando A Bozza, and
Thiago M L Souza, and
Irene Bosch, and
Nathan L Yozwiak, and
Bronwyn L MacInnis, and
Pardis C Sabeti
January 2017,
Virus evolution,
Hayden C Metsky, and
Christian B Matranga, and
Shirlee Wohl, and
Stephen F Schaffner, and
Catherine A Freije, and
Sarah M Winnicki, and
Kendra West, and
James Qu, and
Mary Lynn Baniecki, and
Adrianne Gladden-Young, and
Aaron E Lin, and
Christopher H Tomkins-Tinch, and
Simon H Ye, and
Daniel J Park, and
Cynthia Y Luo, and
Kayla G Barnes, and
Rickey R Shah, and
Bridget Chak, and
Giselle Barbosa-Lima, and
Edson Delatorre, and
Yasmine R Vieira, and
Lauren M Paul, and
Amanda L Tan, and
Carolyn M Barcellona, and
Mario C Porcelli, and
Chalmers Vasquez, and
Andrew C Cannons, and
Marshall R Cone, and
Kelly N Hogan, and
Edgar W Kopp, and
Joshua J Anzinger, and
Kimberly F Garcia, and
Leda A Parham, and
Rosa M Gélvez Ramírez, and
Maria C Miranda Montoya, and
Diana P Rojas, and
Catherine M Brown, and
Scott Hennigan, and
Brandon Sabina, and
Sarah Scotland, and
Karthik Gangavarapu, and
Nathan D Grubaugh, and
Glenn Oliveira, and
Refugio Robles-Sikisaka, and
Andrew Rambaut, and
Lee Gehrke, and
Sandra Smole, and
M Elizabeth Halloran, and
Luis Villar, and
Salim Mattar, and
Ivette Lorenzana, and
Jose Cerbino-Neto, and
Clarissa Valim, and
Wim Degrave, and
Patricia T Bozza, and
Andreas Gnirke, and
Kristian G Andersen, and
Sharon Isern, and
Scott F Michael, and
Fernando A Bozza, and
Thiago M L Souza, and
Irene Bosch, and
Nathan L Yozwiak, and
Bronwyn L MacInnis, and
Pardis C Sabeti
October 2019,
PLoS pathogens,
