Biomaterial Database

Spindle cell subtype of pulmonary clear cell tumor with prominent calcification and malignant potential. 2017

Yinghua Song, and Fangfang Chen, and Caiqing Zhang, and Xiaoyan Lin

Department of Respiratory Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.

Perivascular epithelioid cell tumor of the lung, also known as clear cell "sugar" tumor, is a rare benign tumor arising from perivascular epithelioid cells. Herein, we present a case of spindle cell subtype of pulmonary perivascular epithelioid cell tumor with prominent calcification and malignant potential in a 49-year-old woman. Histologically, the striking feature of this lesion was attributed to the presence of spindle cells arranged in a diffuse pattern, which is a pitfall for diagnosis. However, some of the lesion contained polygonal tumor cells with clear abundant cytoplasm surrounded by thin-walled vascular spaces. The size of the tumor and its Ki-67 index suggested malignant potential, and calcification was another rare characteristic. Immunostaining indicated that the tumor cells were positive not only for HMB-45 and Melan A, but also for CD34 and CD1a. This tumor should be distinguished from tumors with rich spindle cells such as sarcoma, clear cell carcinoma, or metastatic tumors. The patient in this case was alive with no tumor recurrence or metastasis six months after lobectomy.

UI	MeSH Term	Description	Entries
D008175	Lung Neoplasms	Tumors or cancer of the LUNG.	Cancer of Lung,Lung Cancer,Pulmonary Cancer,Pulmonary Neoplasms,Cancer of the Lung,Neoplasms, Lung,Neoplasms, Pulmonary,Cancer, Lung,Cancer, Pulmonary,Cancers, Lung,Cancers, Pulmonary,Lung Cancers,Lung Neoplasm,Neoplasm, Lung,Neoplasm, Pulmonary,Pulmonary Cancers,Pulmonary Neoplasm
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D011013	Pneumonectomy	The excision of lung tissue including partial or total lung lobectomy.	Bronchoscopic Lung Volume Reduction,Endoscopic Lung Volume Reduction,Lung Volume Reduction,Lung Volume Reduction Surgery,Partial Pneumonectomy,Partial Pneumonectomies,Pneumonectomies,Pneumonectomy, Partial,Reduction, Lung Volume,Volume Reduction, Lung
D002114	Calcinosis	Pathologic deposition of calcium salts in tissues.	Calcification, Pathologic,Calcinosis, Tumoral,Microcalcification,Microcalcinosis,Pathologic Calcification,Calcinoses,Calcinoses, Tumoral,Microcalcifications,Microcalcinoses,Tumoral Calcinoses,Tumoral Calcinosis
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014408	Biomarkers, Tumor	Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or BODY FLUIDS. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including HORMONES; ANTIGENS; amino and NUCLEIC ACIDS; ENZYMES; POLYAMINES; and specific CELL MEMBRANE PROTEINS and LIPIDS.	Biochemical Tumor Marker,Cancer Biomarker,Carcinogen Markers,Markers, Tumor,Metabolite Markers, Neoplasm,Tumor Biomarker,Tumor Marker,Tumor Markers, Biochemical,Tumor Markers, Biological,Biochemical Tumor Markers,Biological Tumor Marker,Biological Tumor Markers,Biomarkers, Cancer,Marker, Biochemical Tumor,Marker, Biologic Tumor,Marker, Biological Tumor,Marker, Neoplasm Metabolite,Marker, Tumor Metabolite,Markers, Biochemical Tumor,Markers, Biological Tumor,Markers, Neoplasm Metabolite,Markers, Tumor Metabolite,Metabolite Markers, Tumor,Neoplasm Metabolite Markers,Tumor Markers, Biologic,Tumor Metabolite Marker,Biologic Tumor Marker,Biologic Tumor Markers,Biomarker, Cancer,Biomarker, Tumor,Cancer Biomarkers,Marker, Tumor,Markers, Biologic Tumor,Markers, Carcinogen,Metabolite Marker, Neoplasm,Metabolite Marker, Tumor,Neoplasm Metabolite Marker,Tumor Biomarkers,Tumor Marker, Biochemical,Tumor Marker, Biologic,Tumor Marker, Biological,Tumor Markers,Tumor Metabolite Markers
D047368	Tumor Burden	The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.	Tumor Load,Tumor Volume,Tumor Weight,Burden, Tumor,Load, Tumor,Loads, Tumor,Tumor Loads,Tumor Weights,Volume, Tumor,Weight, Tumor,Weights, Tumor
D054973	Perivascular Epithelioid Cell Neoplasms	A family of mesenchymal tumors composed of histologically and immunohistochemically distinctive perivascular epithelioid cells. These cells do not have a normal anatomic homolog. (From Fletcher CDM, et. al., World Health Organization Classification of Tumors: Pathology and Genetics of Tumors of Soft Tissue and Bone, 2002).	Clear-Cell Myomelanocytic Tumor,Clear-Cell Myomelanocytic Tumors,Clear-Cell Sugar Tumor,Clear-Cell Sugar Tumors,PEComa,PEComas,Perivascular Epithelioid Cell Neoplasm,Perivascular Epithelioid Cell Tumor,CCMMT,Neoplasms, Perivascular Epithelioid Cell,Perivascular Epithelioid Cell Tumors,Clear Cell Myomelanocytic Tumor,Clear Cell Myomelanocytic Tumors,Clear Cell Sugar Tumor,Clear Cell Sugar Tumors,Myomelanocytic Tumor, Clear-Cell,Myomelanocytic Tumors, Clear-Cell,Sugar Tumor, Clear-Cell,Sugar Tumors, Clear-Cell,Tumor, Clear-Cell Myomelanocytic,Tumor, Clear-Cell Sugar,Tumors, Clear-Cell Myomelanocytic,Tumors, Clear-Cell Sugar
D058950	Melanoma-Specific Antigens	Cellular antigens that are specific for MELANOMA cells.	Melanoma Antigens,Antigens, Melanoma,Antigens, Melanoma-Specific,Melanoma Specific Antigens