-transparent.png){kind=logo}
The reaction catalyzed by cysteamine oxygenase on cysteamine in the presence of phenazine methosulphate as cofactor like compound is inhibited by nitroblue tetrazolium, a scavenger of superoxide ions. The reaction is not inhibited by superoxide dismutase and allyl alcohol and it is not activated by superoxide ions produced in solution. Nitroblue tetrazolium is reduced by cysteamine or mercaptoethanol and phenazine methosulphate. This reaction is completely inhibited by superoxide dismutase. In the presence of cysteamine oxygenase the reduction with mercaptoethanol is greatly enhanced and it is only partially inhibited by superoxide dismutase. According to these data a reaction mechanism is proposed in which superoxide ions and thiyl radicals are produced at the active site during catalysis.
G Ricci, and
S Duprè, and
G Federici, and
M Nardini, and
G Spoto, and
D Cavallini
December 1975,
Molecular and cellular biochemistry,
G Ricci, and
S Duprè, and
G Federici, and
M Nardini, and
G Spoto, and
D Cavallini
June 1992,
The International journal of biochemistry,
G Ricci, and
S Duprè, and
G Federici, and
M Nardini, and
G Spoto, and
D Cavallini
April 1984,
Prostaglandins, leukotrienes, and medicine,
G Ricci, and
S Duprè, and
G Federici, and
M Nardini, and
G Spoto, and
D Cavallini
October 1977,
The Biochemical journal,
G Ricci, and
S Duprè, and
G Federici, and
M Nardini, and
G Spoto, and
D Cavallini
June 2007,
Natural product reports,
G Ricci, and
S Duprè, and
G Federici, and
M Nardini, and
G Spoto, and
D Cavallini
April 1968,
European journal of biochemistry,
G Ricci, and
S Duprè, and
G Federici, and
M Nardini, and
G Spoto, and
D Cavallini
October 1978,
Biochimica et biophysica acta,
G Ricci, and
S Duprè, and
G Federici, and
M Nardini, and
G Spoto, and
D Cavallini
December 1980,
Nature,
G Ricci, and
S Duprè, and
G Federici, and
M Nardini, and
G Spoto, and
D Cavallini
January 1972,
Physiological chemistry and physics,
G Ricci, and
S Duprè, and
G Federici, and
M Nardini, and
G Spoto, and
D Cavallini
August 1985,
Archives internationales de pharmacodynamie et de therapie,
