Biomaterial Database

Erythropoietin: in vitro and in vivo studies of the regulation of erythropoiesis. 1988

J W Adamson

Department of Medicine, University of Washington, Seattle.

The application of recombinant DNA technology to the field of hematology has contributed greatly to our understanding of Epo gene structure and regulation, cellular expression and regulation of hormone production, pharmacokinetics, receptor cell biology and, ultimately, the value of this hormone as a therapeutic. Areas that will undoubtedly prove fruitful for future research include the mechanisms by which hypoxia influences gene expression, the structure/function relationships of the Epo molecule, isolation and cloning of the gene for the Epo receptor, mechanisms of transmembrane signaling and nuclear activation, and the further application of recombinant human Epo in the treatment of other diseases. Epo is but one example of the contribution of modern biology to the understanding of growth factor regulation of hematopoiesis and to the availability of these factors for clinical trial.

UI	MeSH Term	Description	Entries
D011956	Receptors, Cell Surface	Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.	Cell Surface Receptor,Cell Surface Receptors,Hormone Receptors, Cell Surface,Receptors, Endogenous Substances,Cell Surface Hormone Receptors,Endogenous Substances Receptors,Receptor, Cell Surface,Surface Receptor, Cell
D004920	Erythropoiesis	The production of red blood cells (ERYTHROCYTES). In humans, erythrocytes are produced by the YOLK SAC in the first trimester; by the liver in the second trimester; by the BONE MARROW in the third trimester and after birth. In normal individuals, the erythrocyte count in the peripheral blood remains relatively constant implying a balance between the rate of erythrocyte production and rate of destruction.	Erythropoieses
D004921	Erythropoietin	Glycoprotein hormone, secreted chiefly by the KIDNEY in the adult and the LIVER in the FETUS, that acts on erythroid stem cells of the BONE MARROW to stimulate proliferation and differentiation.
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D017467	Receptors, Erythropoietin	Cell surface proteins that bind erythropoietin with high affinity and trigger intracellular changes influencing the behavior of cells.	Erythropoietin Receptors,Erythropoietin Receptor,Receptor, Erythropoietin