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The Mr = 33,000 catalytic fragment of rabbit skeletal muscle type 1 protein phosphatase was digested with trypsin after reduction and alkylation. The resulting peptides were isolated, subjected to automated Edman degradation, and their sequences compared to the deduced peptide sequence of the bovine type 2A protein phosphatase cDNA. Of 10 tryptic peptides from the type 1 phosphatase that were sequenced, nine showed a high degree of homology with the type 2A phosphatase. This provides the first direct sequence comparison suggesting that the type 1 and type 2 protein phosphatases, distinguished functionally by their substrate specificities and sensitivity to inhibitors, make up part of a family of closely related gene products with similar structures.
G L Johnson, and
D L Brautigan, and
C Shriner, and
S Jaspers, and
J Arino, and
J E Mole, and
T B Miller, and
M C Mumby
September 1993,
The Journal of biological chemistry,
G L Johnson, and
D L Brautigan, and
C Shriner, and
S Jaspers, and
J Arino, and
J E Mole, and
T B Miller, and
M C Mumby
October 1998,
Regulatory peptides,
G L Johnson, and
D L Brautigan, and
C Shriner, and
S Jaspers, and
J Arino, and
J E Mole, and
T B Miller, and
M C Mumby
January 1998,
Acta anatomica,
G L Johnson, and
D L Brautigan, and
C Shriner, and
S Jaspers, and
J Arino, and
J E Mole, and
T B Miller, and
M C Mumby
October 1991,
Molecular pharmacology,
G L Johnson, and
D L Brautigan, and
C Shriner, and
S Jaspers, and
J Arino, and
J E Mole, and
T B Miller, and
M C Mumby
November 1990,
The Journal of biological chemistry,
G L Johnson, and
D L Brautigan, and
C Shriner, and
S Jaspers, and
J Arino, and
J E Mole, and
T B Miller, and
M C Mumby
August 1989,
The Biochemical journal,
G L Johnson, and
D L Brautigan, and
C Shriner, and
S Jaspers, and
J Arino, and
J E Mole, and
T B Miller, and
M C Mumby
January 1992,
Preparative biochemistry,
G L Johnson, and
D L Brautigan, and
C Shriner, and
S Jaspers, and
J Arino, and
J E Mole, and
T B Miller, and
M C Mumby
January 1996,
Biochemistry and cell biology = Biochimie et biologie cellulaire,
G L Johnson, and
D L Brautigan, and
C Shriner, and
S Jaspers, and
J Arino, and
J E Mole, and
T B Miller, and
M C Mumby
February 1993,
Plant molecular biology,
G L Johnson, and
D L Brautigan, and
C Shriner, and
S Jaspers, and
J Arino, and
J E Mole, and
T B Miller, and
M C Mumby
November 1995,
The American journal of physiology,
