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Body sodium was measured repeatedly by a whole-body counting method (22Na) in control and deoxycorticosterone acetate (DOCA)-treated Wistar rats taking a sodium-free pelleted diet and drinking a choice of H2O and either 0.5% NaCl or 0.1% NaCl (n = 11 per group, four groups). Body sodium was higher in DOCA-treated than in control rats and higher in rats on 0.5% NaCl than in those on 0.1% NaCl. These differences persisted even when all sodium intake was stopped. An intraperitoneal NaCl load was excreted at least as rapidly by the DOCA-treated as by the control rats. Commencement of excretion was slower in the rats on 0.1% NaCl than in those on 0.5% NaCl. It is concluded that DOCA raises the basal level of body sodium but does not slow down the excretion of sodium in the body in excess of the basal level.
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