-transparent.png){kind=logo}
Blood lymphocyte subpopulations (Leu 4+ cells = pan-T cells, Leu 3a+ cells = helper/inducer cells, and Leu 2a+ cells = suppressor/cytotoxic cells), thyroid-stimulating immunoglobulins, microsomal antibodies and antibodies against thyroglobulin were determined in 10 patients with hyperthyroidism due to single autonomously functioning thyroid nodules (ATN), 11 patients with hyperthyroidism due to Graves' disease (GD) and in 20 normal subjects. Thyroidectomy was performed in 8 of the patients with ATN and in 6 of those with GD after 3 weeks of antithyroid drug treatment with methimazole. Lymphocytic infiltration of thyroid tissue, the amount of the various lymphocyte subsets (Leu 4+, Leu 3a+, and Leu 2a+ T cells as well as B+ B cells) in the thyroid gland, as well as the expression of the histocompatibility antigen HLA-DR on thyrocytes and intrathyroidal lymphocytes were examined. Blood Leu 4+ cells were reduced due to a lack of Leu 2a+ cells in patients with ATN and GD when compared to normal subjects. Thyroid-stimulating immunoglobulins were detected in all patients with ATN and GD, but in none of the normal subjects. Lymphocytic infiltration of thyroid tissue was present in patients with ATN and GD. The various lymphocyte subsets in the thyroid gland did not differ between the two patient groups. DR expression on thyrocytes was seen in 6 of the patients operated for ATN and in 5 of those who underwent surgery for GD. Infiltration with DR+-T lymphocytes was found in all thyroid glands investigated. Thus immunological findings usually classified as proof for the autoimmune origin of GD exist also in patients with ATN. An overlap in the pathogenetic background of both diseases seems possible.
B Grubeck-Loebenstein, and
K Derfler, and
H Kassal, and
W Knapp, and
K Krisch, and
K Liszka, and
P P Smyth, and
W Waldhäusl
June 1984,
Nuklearmedizin. Nuclear medicine,
B Grubeck-Loebenstein, and
K Derfler, and
H Kassal, and
W Knapp, and
K Krisch, and
K Liszka, and
P P Smyth, and
W Waldhäusl
December 1989,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
B Grubeck-Loebenstein, and
K Derfler, and
H Kassal, and
W Knapp, and
K Krisch, and
K Liszka, and
P P Smyth, and
W Waldhäusl
February 1990,
Nuklearmedizin. Nuclear medicine,
B Grubeck-Loebenstein, and
K Derfler, and
H Kassal, and
W Knapp, and
K Krisch, and
K Liszka, and
P P Smyth, and
W Waldhäusl
January 1994,
Cell transplantation,
B Grubeck-Loebenstein, and
K Derfler, and
H Kassal, and
W Knapp, and
K Krisch, and
K Liszka, and
P P Smyth, and
W Waldhäusl
October 1991,
Journal of endocrinological investigation,
B Grubeck-Loebenstein, and
K Derfler, and
H Kassal, and
W Knapp, and
K Krisch, and
K Liszka, and
P P Smyth, and
W Waldhäusl
January 1977,
Acta chirurgica Scandinavica,
B Grubeck-Loebenstein, and
K Derfler, and
H Kassal, and
W Knapp, and
K Krisch, and
K Liszka, and
P P Smyth, and
W Waldhäusl
January 1937,
Transactions of the American Clinical and Climatological Association,
B Grubeck-Loebenstein, and
K Derfler, and
H Kassal, and
W Knapp, and
K Krisch, and
K Liszka, and
P P Smyth, and
W Waldhäusl
June 1966,
Medizinische Klinik,
B Grubeck-Loebenstein, and
K Derfler, and
H Kassal, and
W Knapp, and
K Krisch, and
K Liszka, and
P P Smyth, and
W Waldhäusl
January 1984,
Journal of biological response modifiers,
B Grubeck-Loebenstein, and
K Derfler, and
H Kassal, and
W Knapp, and
K Krisch, and
K Liszka, and
P P Smyth, and
W Waldhäusl
January 1955,
The Heart bulletin,
