-transparent.png){kind=logo}
Human pancreatic growth hormone-releasing factor (GRF-44-NH2) stimulated growth hormone (GH) secretion and intracellular cyclic AMP levels in cultured pituitary cells from both sheep and rat. Somatostatin (SRIF), over a wide range of doses and time, showed no significant effect on the elevated cyclic AMP levels in sheep cells, but did block the GH release in a dose-dependent manner. In rat cells, however, SRIF inhibited GRF-stimulated cyclic AMP levels by 75% maximum (still 8-fold greater than the basal levels) and GH release to almost half the basal value. We conclude that somatostatin inhibits GRF-elevated cyclic AMP levels in rat pituitary cells but not in sheep cells.
G J Law, and
K P Ray, and
M Wallis
January 1974,
Neuroendocrinology,
G J Law, and
K P Ray, and
M Wallis
June 1985,
Biochemical and biophysical research communications,
G J Law, and
K P Ray, and
M Wallis
July 1986,
The Journal of endocrinology,
G J Law, and
K P Ray, and
M Wallis
June 1986,
Molecular and cellular endocrinology,
G J Law, and
K P Ray, and
M Wallis
July 1977,
The Journal of clinical endocrinology and metabolism,
G J Law, and
K P Ray, and
M Wallis
October 1986,
The Journal of biological chemistry,
G J Law, and
K P Ray, and
M Wallis
August 1989,
Endocrinology,
G J Law, and
K P Ray, and
M Wallis
April 1983,
Endocrinology,
G J Law, and
K P Ray, and
M Wallis
June 1973,
Metabolism: clinical and experimental,
G J Law, and
K P Ray, and
M Wallis
October 1984,
Molecular and cellular endocrinology,
