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In a case of acute lymphoblastic leukemia, two distinct types of leukemia blast cells could be identified throughout the course of the disease. The initially dominant type of blast cell was sensitive to chemotherapy; the other was drug-resistant, gradually becoming dominant as the disease progressed. The cell types could be clearly separated by their morphologic and surface membrane marker characteristics. The same chromosomal constitution was present in both types of blast cells, indicating a common clonal origin. Additional chromosomal abnormalities were present in the later stages of the disease, demonstrating that a distinct subclone had proliferated. This study illustrates that in some cases of acute leukemia, disease relapse is caused by growth of drug-resistant subclones that may be clearly identified by changes in morphology and surface membrane marker characteristics.
A H Goldstone, and
B A McVerry, and
G Janossy, and
H Walker
February 1996,
Cancer genetics and cytogenetics,
A H Goldstone, and
B A McVerry, and
G Janossy, and
H Walker
September 1992,
Blood,
A H Goldstone, and
B A McVerry, and
G Janossy, and
H Walker
July 2015,
Nature immunology,
A H Goldstone, and
B A McVerry, and
G Janossy, and
H Walker
October 1985,
Blood,
A H Goldstone, and
B A McVerry, and
G Janossy, and
H Walker
October 1981,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
A H Goldstone, and
B A McVerry, and
G Janossy, and
H Walker
June 2011,
Blood,
A H Goldstone, and
B A McVerry, and
G Janossy, and
H Walker
August 2020,
Zhonghua nei ke za zhi,
A H Goldstone, and
B A McVerry, and
G Janossy, and
H Walker
January 2015,
Stem cells international,
A H Goldstone, and
B A McVerry, and
G Janossy, and
H Walker
April 1992,
Leukemia,
A H Goldstone, and
B A McVerry, and
G Janossy, and
H Walker
November 2016,
Oncotarget,
