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The histochemical activities of nonspecific acid and alkaline phosphatases, NADH- and NADPH-tetrazolium reductases, alpha-glycerophosphate dehydrogenase, succinate dehydrogenase, isocitrate dehydrogenase, lactate dehydrogenase and glucose-6-phosphate dehydrogenase were investigated in kidneys from rats treated with lithium and lithium plus neuroleptics. During the first 8 weeks of lithium treatment the activity of NADH-tetrazolium reductase, succinate dehydrogenase and alpha-glycerophosphate dehydrogenase activity in the collecting ducts increased. The other enzymes did not change. After 8 weeks of treatment no further changes in enzyme activity occurred. Withdrawal of lithium caused normalization of enzyme activity after 8 weeks. A decrease in concentration ability was found in parallel with the increase in enzyme activities (p less than 0.001). The changes in enzyme activity were not significantly correlated to morphological changes in the collecting ducts. Treatment with neuroleptics alone caused no change in enzyme activity. During combined lithium plus neuroleptic treatment the enzyme activities changed in a similar way as during lithium therapy, but the changes were less pronounced. In parallel, a less pronounced decrease in concentration ability was found during this treatment.
T Nørgaard, and
P Faarup, and
B B Hansen, and
A R Kristensen, and
S Christensen
July 1977,
Kidney international,
T Nørgaard, and
P Faarup, and
B B Hansen, and
A R Kristensen, and
S Christensen
March 1982,
Kidney international,
T Nørgaard, and
P Faarup, and
B B Hansen, and
A R Kristensen, and
S Christensen
January 1985,
Life support systems : the journal of the European Society for Artificial Organs,
T Nørgaard, and
P Faarup, and
B B Hansen, and
A R Kristensen, and
S Christensen
June 1980,
The American journal of psychiatry,
T Nørgaard, and
P Faarup, and
B B Hansen, and
A R Kristensen, and
S Christensen
June 1962,
[Hokkaido igaku zasshi] The Hokkaido journal of medical science,
T Nørgaard, and
P Faarup, and
B B Hansen, and
A R Kristensen, and
S Christensen
December 1990,
Danish medical bulletin,
T Nørgaard, and
P Faarup, and
B B Hansen, and
A R Kristensen, and
S Christensen
January 1980,
Acta medica Scandinavica,
T Nørgaard, and
P Faarup, and
B B Hansen, and
A R Kristensen, and
S Christensen
March 1979,
The American journal of psychiatry,
T Nørgaard, and
P Faarup, and
B B Hansen, and
A R Kristensen, and
S Christensen
January 1989,
Therapie,
T Nørgaard, and
P Faarup, and
B B Hansen, and
A R Kristensen, and
S Christensen
June 1984,
Toxicology letters,
