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Atropine and glycopyrrolate were compared in a mixture with neostigmine for reversal of neuromuscular blockade in patients undergoing open heart surgery. In patients not receiving beta-blocking drugs, glycopyrrolate was shown to possess advantages over atropine in terms of a lower initial increase in heart rate, better protection against the muscarinic effects of neostigmine, and smaller increases in rate-pressure product. The concomitant administration of beta-adrenergic blocking therapy significantly attenuated the effect of reversal on heart rate and the differences between atropine and glycopyrrolate were not significant. There was no difference in the incidence of arrhythmias between patients who received beta-blocking drugs and those who did not.
M G Salem, and
J C Richardson, and
G A Meadows, and
G Lamplugh, and
K M Lai
August 1977,
British journal of anaesthesia,
M G Salem, and
J C Richardson, and
G A Meadows, and
G Lamplugh, and
K M Lai
January 1972,
Anesthesia and analgesia,
M G Salem, and
J C Richardson, and
G A Meadows, and
G Lamplugh, and
K M Lai
August 1981,
Anesthesia and analgesia,
M G Salem, and
J C Richardson, and
G A Meadows, and
G Lamplugh, and
K M Lai
March 2007,
Anesthesia and analgesia,
M G Salem, and
J C Richardson, and
G A Meadows, and
G Lamplugh, and
K M Lai
August 1980,
Acta anaesthesiologica Scandinavica,
M G Salem, and
J C Richardson, and
G A Meadows, and
G Lamplugh, and
K M Lai
July 1991,
Acta anaesthesiologica Scandinavica,
M G Salem, and
J C Richardson, and
G A Meadows, and
G Lamplugh, and
K M Lai
September 1980,
Anaesthesia,
M G Salem, and
J C Richardson, and
G A Meadows, and
G Lamplugh, and
K M Lai
January 1977,
Anesthesia and analgesia,
M G Salem, and
J C Richardson, and
G A Meadows, and
G Lamplugh, and
K M Lai
December 1988,
Ma zui xue za zhi = Anaesthesiologica Sinica,
M G Salem, and
J C Richardson, and
G A Meadows, and
G Lamplugh, and
K M Lai
October 1983,
British journal of anaesthesia,
